CCT251921
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MedKoo CAT#: 206577

CAS#: 1607837-31-9

Description: CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.

Chemical Structure

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CCT251921
CAS# 1607837-31-9
Instruction

Theoretical Analysis

MedKoo Cat#: 206577
Name: CCT251921
CAS#: 1607837-31-9
Chemical Formula: C21H23ClN6O
Exact Mass: 410.16
Molecular Weight: 410.906
Elemental Analysis: C, 61.38; H, 5.64; Cl, 8.63; N, 20.45; O, 3.89

Price and Availability

Size Price Availability Quantity
10mg USD 550 2 Weeks
50mg USD 1650 2 Weeks
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Synonym: CCT251921; CCT-251921; CCT 251921; CAS#1607837-31-9

IUPAC/Chemical Name: 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

InChi Key: VPJXPDLMACOGIZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23ClN6O/c1-27-16-3-2-13(10-14(16)11-26-27)15-12-25-19(23)17(22)18(15)28-8-5-21(6-9-28)4-7-24-20(21)29/h2-3,10-12H,4-9H2,1H3,(H2,23,25)(H,24,29)

SMILES Code: O=C1NCCC12CCN(C3=C(Cl)C(N)=NC=C3C4=CC5=C(N(C)N=C5)C=C4)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
Aurélie Mallinger, Kai Schiemann, Christian Rink, Frank Stieber, Michel Calderini, Simon Crumpler, Mark Stubbs, Olajumoke Adeniji-Popoola, Oliver Poeschke, Michael Busch, Paul Czodrowski, Djordje Musil, Daniel Schwarz, Maria-Jesus Ortiz-Ruiz, Richard Schneider, Ching Thai, Melanie Valenti, Alexis de Haven Brandon, Rosemary Burke, Paul Workman, Trevor Dale, Dirk Wienke, Paul A. Clarke, Christina Esdar, Florence I. Raynaud, Suzanne A. Eccles, Felix Rohdich, and Julian Blagg, Publication Date (Web): January 21, 2016 (Article), DOI: 10.1021/acs.jmedchem.5b01685