WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206501
CAS#: 1821428-35-6
Description: AZD0156 is an orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy.
MedKoo Cat#: 206501
Name: AZD0156
CAS#: 1821428-35-6
Chemical Formula: C26H31N5O3
Exact Mass: 461.2427
Molecular Weight: 461.566
Elemental Analysis: C, 67.66; H, 6.77; N, 15.17; O, 10.40
AZD0156, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: AZD0156; AZD-0156; AZD 0156.
IUPAC/Chemical Name: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one
InChi Key: AOTRIQLYUAFVSC-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3
SMILES Code: O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3
The following data is based on the product molecular weight 461.566 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
