Tiaprofenic acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318868

CAS#: 33005-95-7

Description: Tiaprofenic acid is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain Long-term use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.

Chemical Structure

Tiaprofenic acid
CAS# 33005-95-7

Theoretical Analysis

MedKoo Cat#: 318868
Name: Tiaprofenic acid
CAS#: 33005-95-7
Chemical Formula: C14H12O3S
Exact Mass: 260.0507
Molecular Weight: 260.307
Elemental Analysis: C, 64.60; H, 4.65; O, 18.44; S, 12.32

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 850 2 Weeks
200mg USD 1450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

Tiaprofenic acid, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).

Synonym: Tiaprofenic acid; trade names Surgam, Surgamyl and Tiaprofen.

IUPAC/Chemical Name: 2-(5-benzoyl-2-thienyl)propanoic acid


InChi Code: InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)

SMILES Code: CC(C1=CC=C(C(C2=CC=CC=C2)=O)S1)C(O)=O

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 260.307 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Moore RA, Derry S, Moore M, McQuay HJ. Single dose oral tiaprofenic acid for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007542. doi: 10.1002/14651858.CD007542.pub2. Review. PubMed PMID: 19821426; PubMed Central PMCID: PMC4170996.

2: Andreassen KH, Eldrup J, Hansen RI, Oster S. Tiaprofenic acid-induced cystitis--three cases and a literature review. Scand J Urol Nephrol. 1999 Dec;33(6):408-10. Review. PubMed PMID: 10636583.

3: Crew JP, Donat R, Roskell D, Fellows GJ. Bilateral ureteric obstruction secondary to the prolonged use of tiaprofenic acid. Br J Clin Pract. 1997 Jan-Feb;51(1):59-60. Review. PubMed PMID: 9158277.

4: Davies NM. Clinical pharmacokinetics of tiaprofenic acid and its enantiomers. Clin Pharmacokinet. 1996 Nov;31(5):331-47. Review. PubMed PMID: 9118583.

5: Plosker GL, Wagstaff AJ. Tiaprofenic acid. A reappraisal of its pharmacological properties and use in the management of rheumatic diseases. Drugs. 1995 Dec;50(6):1050-75. Review. PubMed PMID: 8612471.

6: Famaey JP. Symposium on therapeutic aspects of tiaprofenic acid. Drugs. 1988;35 Suppl 1:1-3. Review. PubMed PMID: 3282866.

7: Sorkin EM, Brogden RN. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs. 1985 Mar;29(3):208-35. Review. PubMed PMID: 3886353.

8: Poletto B. Tiaprofenic acid. Clin Rheum Dis. 1984 Aug;10(2):333-51. Review. PubMed PMID: 6391794.