WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407214
CAS#: 1620692-60-5
Description: KPU-300 is a potent and selective antimicrotubule agent. KPU-300 exhibited a potent cytotoxicity with an IC50 value of 7.0 nM against HT-29 cells, by strongly binding to tubulin (K d = 1.3 μM) and inducing microtubule depolymerization.
MedKoo Cat#: 407214
Name: KPU-300
CAS#: 1620692-60-5
Chemical Formula: C24H17N3O3
Exact Mass: 395.12699
Molecular Weight: 395.418
Elemental Analysis: C, 72.90; H, 4.33; N, 10.63; O, 12.14
Synonym: KPU-300; KPU 300; KPU300.
IUPAC/Chemical Name: (E)-3-((E)-3-benzoylbenzylidene)-6-(pyridin-2-ylmethylene)piperazine-2,5-dione
InChi Key: CDRIOEPHHOSTPX-OZNQKUEASA-N
InChi Code: InChI=1S/C24H17N3O3/c28-22(17-8-2-1-3-9-17)18-10-6-7-16(13-18)14-20-23(29)27-21(24(30)26-20)15-19-11-4-5-12-25-19/h1-15H,(H,26,30)(H,27,29)/b20-14+,21-15+
SMILES Code: O=C(/C(NC/1=O)=C\C2=CC=CC(C(C3=CC=CC=C3)=O)=C2)NC1=C\C4=NC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 395.418 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K,
Yakushiji F, Miura M, Usui T, Hayashi Y. Development of a new
benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a
2-pyridine structure. ACS Med Chem Lett. 2014 Jul 23;5(10):1094-8. doi:
10.1021/ml5001883. eCollection 2014 Oct 9. PubMed PMID: 25313318; PubMed Central
PMCID: PMC4190642.
