Chlorogenic Acid
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MedKoo CAT#: 600122

CAS#: 327-97-9

Description: Chlorogenic acid (CGA) is a natural chemical compound which is the ester of caffeic acid and (-)-quinic acid. It is an important biosynthetic intermediate in lignin biosynthesis. This compound, known as an antioxidant, may also slow the release of glucose into the bloodstream after a meal. The term chlorogenic acids can also refer to a related family of esters of hydroxycinnamic acids (caffeic acid, ferulic acid and p-coumaric acid) with quinic acid. Chlorogenic acids contain no chlorine.

Chemical Structure

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Chlorogenic Acid
CAS# 327-97-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 600122
Name: Chlorogenic Acid
CAS#: 327-97-9
Chemical Formula: C16H18O9
Exact Mass: 354.10
Molecular Weight: 354.310
Elemental Analysis: C, 54.24; H, 5.12; O, 40.64

Price and Availability

Size Price Availability Quantity
1g USD 285 2 Weeks
5g USD 650 2 Weeks
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Synonym: 3(34Dihydroxycinnamoyl)quinate; 3(34Dihydroxycinnamoyl)quinic acid; 3Caffeoylquinate; 3Caffeoylquinic acid; 3CQA; 3OCaffeoylquinic acid; Chlorogenate; Heriguard; 3transCaffeoylquinic acid

IUPAC/Chemical Name: (1S,3R,4R,5R)-3-{[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid

InChi Key: CWVRJTMFETXNAD-XYXZIBEBSA-N

InChi Code: InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2-/t11-,12-,14-,16+/m1/s1

SMILES Code: O=C([C@@]1(O)C[C@@H](OC(/C=C\C2=CC=C(O)C(O)=C2)=O)[C@H](O)[C@H](O)C1)O

Appearance: White to light yellow solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Chlorogenic acid plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
In vitro activity: Treating UV-induced skin fibroblast cells with CA (chlorogenic acid) decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. Reference: PeerJ. 2021; 9: e11419. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272460/
In vivo activity: The mice in the HFD group showed significantly elevated serum transaminase, FBG, blood lipids and HOMA-IR (p < 0.05). After treatment with CGA (chlorogenic acid), the serum transaminase, FBG, blood lipids and HOMA-IR significantly decreased (p < 0.05) (Figure 2). Reference: Front Pharmacol. 2021; 12: 693048. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278021/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 73.7 207.93
DMF 71.0 200.39
Ethanol 48.0 135.47
PBS (pH 7.2) 25.0 70.56
Water 18.0 50.80

Preparing Stock Solutions

The following data is based on the product molecular weight 354.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Girsang E, Ginting CN, Lister INE, Gunawan KY, Widowati W. Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell. PeerJ. 2021 Jul 7;9:e11419. doi: 10.7717/peerj.11419. PMID: 34277144; PMCID: PMC8272460. 2. Zhang S, Sun B, Wang D, Liu Y, Li J, Qi J, Zhang Y, Bai C, Liang S. Chlorogenic Acid Ameliorates Damage Induced by Fluorene-9-Bisphenol in Porcine Sertoli Cells. Front Pharmacol. 2021 Jun 9;12:678772. doi: 10.3389/fphar.2021.678772. PMID: 34177588; PMCID: PMC8219976. 3. Shi A, Li T, Zheng Y, Song Y, Wang H, Wang N, Dong L, Shi H. Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1. Front Pharmacol. 2021 Jun 30;12:693048. doi: 10.3389/fphar.2021.693048. PMID: 34276380; PMCID: PMC8278021. 4. Chen Q, Lei YQ, Liu JF, Wang ZC, Cao H. Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-κB signaling. Brain Res. 2021 Sep 15;1767:147572. doi: 10.1016/j.brainres.2021.147572. Epub 2021 Jun 30. PMID: 34216581.
In vitro protocol: 1. Girsang E, Ginting CN, Lister INE, Gunawan KY, Widowati W. Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell. PeerJ. 2021 Jul 7;9:e11419. doi: 10.7717/peerj.11419. PMID: 34277144; PMCID: PMC8272460. 2. Zhang S, Sun B, Wang D, Liu Y, Li J, Qi J, Zhang Y, Bai C, Liang S. Chlorogenic Acid Ameliorates Damage Induced by Fluorene-9-Bisphenol in Porcine Sertoli Cells. Front Pharmacol. 2021 Jun 9;12:678772. doi: 10.3389/fphar.2021.678772. PMID: 34177588; PMCID: PMC8219976.
In vivo protocol: 1. Shi A, Li T, Zheng Y, Song Y, Wang H, Wang N, Dong L, Shi H. Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1. Front Pharmacol. 2021 Jun 30;12:693048. doi: 10.3389/fphar.2021.693048. PMID: 34276380; PMCID: PMC8278021. 2. Chen Q, Lei YQ, Liu JF, Wang ZC, Cao H. Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-κB signaling. Brain Res. 2021 Sep 15;1767:147572. doi: 10.1016/j.brainres.2021.147572. Epub 2021 Jun 30. PMID: 34216581.

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1: Meng S, Cao J, Feng Q, Peng J, Hu Y. Roles of chlorogenic Acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Alternat Med. 2013;2013:801457. doi: 10.1155/2013/801457. Epub 2013 Aug 25. Review. PubMed PMID: 24062792; PubMed Central PMCID: PMC3766985.