WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 600112

CAS#: 20362-31-6

Description: Arctiin is a lignan found in many plants of the Asteraceae family, particularly the greater burdock (Arctium lappa) and Centaurea imperialis, and in Trachelospermum asiaticum, Saussurea heteromalla., and Forsythia viridissima. It is the glucoside of arctigenin. Arctiin and arctigenin have shown anticancer effects.

Chemical Structure

CAS# 20362-31-6

Theoretical Analysis

MedKoo Cat#: 600112
Name: Arctiin
CAS#: 20362-31-6
Chemical Formula: C27H34O11
Exact Mass: 534.21011
Molecular Weight: 534.55
Elemental Analysis: C, 60.67; H, 6.41; O, 32.92

Price and Availability

Size Price Availability Quantity
25.0mg USD 160.0 2 Weeks
50.0mg USD 210.0 2 Weeks
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IUPAC/Chemical Name: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-{[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl}oxolan-2-one


InChi Code: InChI=1S/C27H34O11/c1-33-18-6-4-14(10-20(18)34-2)8-16-13-36-26(32)17(16)9-15-5-7-19(21(11-15)35-3)37-27-25(31)24(30)23(29)22(12-28)38-27/h4-7,10-11,16-17,22-25,27-31H,8-9,12-13H2,1-3H3/t16-,17+,22+,23+,24-,25+,27+/m0/s1

SMILES Code: O=C1OC[C@H](CC2=CC=C(OC)C(OC)=C2)[C@H]1CC3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 534.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Cha HJ, Lee GT, Lee KS, Lee KK, Hong JT, Lee NK, Kim SY, Lee BM, An IS, Hahn HJ, Ahn KJ, Lee SJ, An S, Bae S. Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes. Mol Med Rep. 2014 Jun 13. doi: 10.3892/mmr.2014.2326. [Epub ahead of print] PubMed PMID: 24926940.

2: Lee GT, Cha HJ, Lee KS, Lee KK, Hong JT, Ahn KJ, An IS, An S, Bae S. Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes. Int J Mol Med. 2014 Mar;33(3):640-8. doi: 10.3892/ijmm.2014.1616. Epub 2014 Jan 7. PubMed PMID: 24398562.

3: Lu LC, Zhang R, Song MB, Zhou SW, Qian GS. Optimization of extraction and purification of arctiin from Fructus arctii and its protection against glucose-induced rat aortic endothelial cell injury. Cell Biochem Biophys. 2014 May;69(1):93-101. doi: 10.1007/s12013-013-9775-5. PubMed PMID: 24163109.

4: Han XY, Wang W, Tan RQ, Dou DQ. [Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration]. Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):432-4. Chinese. PubMed PMID: 23668024.

5: Wang W, Pan Q, Han XY, Wang J, Tan RQ, He F, Dou DQ, Kang TG. Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC. Fitoterapia. 2013 Apr;86:6-12. doi: 10.1016/j.fitote.2013.01.016. Epub 2013 Feb 1. PubMed PMID: 23380537.

6: Ma ST, Liu DL, Deng JJ, Niu R, Liu RB. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res. 2013 Oct;27(10):1474-80. doi: 10.1002/ptr.4884. Epub 2012 Nov 12. PubMed PMID: 23147865.

7: Lu LC, Zhou W, Li ZH, Yu CP, Li CW, Luo MH, Xie H. Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats. Planta Med. 2012 Aug;78(12):1317-23. doi: 10.1055/s-0032-1314998. Epub 2012 Jun 29. PubMed PMID: 22753037.

8: He F, Dou DQ, Sun Y, Zhu L, Xiao HB, Kang TG. Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. Planta Med. 2012 May;78(8):800-6. doi: 10.1055/s-0031-1298433. Epub 2012 Apr 12. Erratum in: Planta Med. 2013 Mar;79(5):368. Fan, He [corrected to He, Fan]; De-Qiang, Dou [corrected to Dou, De-Qiang]; Yu, Sun [corrected to Sun, Yu]; Lin, Zhu [corrected to Zhu, Lin]; Hong-Bin, Xiao [corrected to Xiao, Hong-Bin]; Ting-Guo, Kang [corrected to Kang, Ting-Guo]. PubMed PMID: 22499560.

9: Zhang J, Guo TT, Yang L, Du QS, Hua J, Liu RZ, Tang X. [Effect of arctiin on mouse podocyte epithelial-mesenchymal transition induced by advanced oxidation protein products]. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Mar;32(3):379-82. Chinese. PubMed PMID: 22445988.

10: Lee S, Shin S, Kim H, Han S, Kim K, Kwon J, Kwak JH, Lee CK, Ha NJ, Yim D, Kim K. Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-κB pathways. J Inflamm (Lond). 2011 Jul 7;8(1):16. doi: 10.1186/1476-9255-8-16. PubMed PMID: 21733191; PubMed Central PMCID: PMC3146809.


25.0mg / USD 160.0