NOTA-P2-RM26 | NOTA-conjugated bombesin antagonist | GRPR-targeted tumor imaging

NOTA-P2-RM26
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125674

CAS#: N/A

Description: NOTA-P2-RM26 is a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging

Chemical Structure

NOTA-P2-RM26

CAS# N/A

Instruction

Theoretical Analysis

MedKoo Cat#: 125674
Name: NOTA-P2-RM26
CAS#: N/A
Chemical Formula: C73H110N18O19
Exact Mass: 1,542.82
Molecular Weight: 1,543.790
Elemental Analysis: C, 56.80; H, 7.18; N, 16.33; O, 19.69

Price and Availability

Size	Price	Availability
10mg	USD 1250	2 Weeks
50mg	USD 2050	2 Weeks
100mg	USD 3850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NOTA-P2-RM26; NOTA P2-RM26; NOTA-P2 RM26

IUPAC/Chemical Name: 2,2'-(7-((13R,16S,19S,22S,25S,31S,34R,35R,39S)-31-((1H-imidazol-5-yl)methyl)-19-((1H-indol-3-yl)methyl)-16-(3-amino-3-oxopropyl)-13-benzyl-39-carbamoyl-35-hydroxy-34-isobutyl-25-isopropyl-22,41-dimethyl-2,11,14,17,20,23,26,29,32,37-decaoxo-6,9-dioxa-3,12,15,18,21,24,27,30,33,38-decaazadotetracontyl)-1,4,7-triazonane-1,4-diyl)diacetic acid

InChi Key: MZMIUKVXOOFRJV-JVNLZQJNSA-N

InChi Code: InChI=1S/C73H110N18O19/c1-43(2)29-53(58(92)34-60(94)82-54(67(75)102)30-44(3)4)86-72(107)57(33-49-36-76-42-80-49)83-61(95)37-79-73(108)66(45(5)6)88-68(103)46(7)81-70(105)56(32-48-35-78-51-16-12-11-15-50(48)51)87-69(104)52(17-18-59(74)93)85-71(106)55(31-47-13-9-8-10-14-47)84-63(97)41-110-28-27-109-26-19-77-62(96)38-89-20-22-90(39-64(98)99)24-25-91(23-21-89)40-65(100)101/h8-16,35-36,42-46,52-58,66,78,92H,17-34,37-41H2,1-7H3,(H2,74,93)(H2,75,102)(H,76,80)(H,77,96)(H,79,108)(H,81,105)(H,82,94)(H,83,95)(H,84,97)(H,85,106)(H,86,107)(H,87,104)(H,88,103)(H,98,99)(H,100,101)/t46-,52-,53+,54-,55+,56-,57-,58+,66-/m0/s1

SMILES Code: C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC(C)C)[C@@H](CC(=O)N[C@@H](CC(C)C)C(=O)N)O)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](CC4=CC=CC=C4)NC(=O)COCCOCCNC(=O)CN5CCN(CCN(CC5)CC(=O)O)CC(=O)O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,543.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Varasteh Z, Velikyan I, Lindeberg G, Sörensen J, Larhed M, Sandström M,
Selvaraju RK, Malmberg J, Tolmachev V, Orlova A. Synthesis and characterization
of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor
imaging. Bioconjug Chem. 2013 Jul 17;24(7):1144-53. doi: 10.1021/bc300659k. Epub
2013 Jul 2. PMID: 23763444.

2: Varasteh Z, Aberg O, Velikyan I, Lindeberg G, Sörensen J, Larhed M, Antoni G,
Sandström M, Tolmachev V, Orlova A. In vitro and in vivo evaluation of a
(18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand
for GRPR-targeted tumor imaging. PLoS One. 2013 Dec 3;8(12):e81932. doi:
10.1371/journal.pone.0081932. PMID: 24312607; PMCID: PMC3849266.

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