TU-100

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125482

CAS#: 1310907-71-1

Description: TU-100 is traditionally used in the treatment of chronic gastrointestinal disorders, and often prescribed to relieve abdominal pain, abdominal distention, Crohn’s disease, irritable bowel syndrome, adhesive ileus, and paralytic ileus. TU-100 improves gastrointestinal dysmotility and reduces serum CRP levels in patients with grade B liver damage after hepatectomy.

Chemical Structure

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TU-100
CAS# 1310907-71-1
Instruction

Theoretical Analysis

MedKoo Cat#: 125482
Name: TU-100
CAS#: 1310907-71-1
Chemical Formula: C20H13NO3
Exact Mass: 315.09
Molecular Weight: 315.330
Elemental Analysis: C, 76.18; H, 4.16; N, 4.44; O, 15.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TU-100; TU100; TU 100; Daikenchuto

IUPAC/Chemical Name: 14-methyl-5H-5,12-epiminobenzo[4,5]cyclohepta[1,2-b]naphthalene-6,11,13(12H)-trione

InChi Key: KAYRGFYBCCETPE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13NO3/c1-21-16-10-6-2-3-7-11(10)20(24)17(21)15-14(16)18(22)12-8-4-5-9-13(12)19(15)23/h2-9,16-17H,1H3

SMILES Code: CN1C2C3=C(C1C4=C(C=CC=C4)C2=O)C(=O)C5=C(C=CC=C5)C3=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 315.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yamada S, Morine Y, Imura S, Ikemoto T, Saito Y, Shimizu M, Tsuneyama K,
Nishiyama M, Ishizawa S, Shimada M. Effect of daikenchuto (TU-100) on
carcinogenesis in non-alcoholic steatohepatitis. J Med Invest.
2023;70(1.2):66-73. doi: 10.2152/jmi.70.66. PMID: 37164745.

2: Takasu C, Miyazaki K, Yoshikawa K, Nishi M, Tokunaga T, Kashihara H,
Yoshimoto T, Ogawa H, Morine Y, Shimada M. Effect of TU-100 on Peyer's patches
in a bacterial translocation rat model. Ann Gastroenterol Surg. 2021 Apr
5;5(5):683-691. doi: 10.1002/ags3.12460. PMID: 34585053; PMCID: PMC8452476.

3: Chen S, Morine Y, Saito YU, Yamada S, Teraoku H, Ikemoto T, Shimada M. TU-100
Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor
Microenvironment by Suppressing the TLR4/NF-B/STAT3 Axis. Anticancer Res. 2023
May;43(5):1985-1992. doi: 10.21873/anticanres.16359. PMID: 37097685.

4: Takasu C, Yismaw WG, Kurita N, Yoshikawa K, Kashihara H, Kono T, Shimada M.
TU-100 exerts a protective effect against bacterial translocation by maintaining
the tight junction. Surg Today. 2017 Oct;47(10):1287-1294. doi:
10.1007/s00595-017-1518-6. Epub 2017 Apr 18. PMID: 28421347.

5: Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ,
Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger
ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-
independent effects involving Akt and NF-κB suppression. PLoS One. 2014 May
23;9(5):e97456. doi: 10.1371/journal.pone.0097456. PMID: 24857966; PMCID:
PMC4032249.

6: Wada Y, Tokuda K, Morine Y, Okikawa S, Yamashita S, Ikemoto T, Imura S, Saito
Y, Yamada S, Shimada M. The inhibitory effect of TU-100 on hepatic stellate cell
activation in the tumor microenvironment. Oncotarget. 2020 Dec
8;11(49):4593-4604. doi: 10.18632/oncotarget.27835. PMID: 33346211; PMCID:
PMC7733620.

7: Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M,
Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB.
Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and
APCmin/+ Mouse Models of Experimental Colon Cancer. Phytother Res.
2017 Jan;31(1):90-99. doi: 10.1002/ptr.5735. Epub 2016 Oct 12. PMID: 27730672;
PMCID: PMC5590753.

8: Hasebe T, Ueno N, Musch MW, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J,
Yamamoto M, Kono T, Inaba Y, Fujiya M, Kohgo Y, Chang EB. Daikenchuto (TU-100)
shapes gut microbiota architecture and increases the production of ginsenoside
metabolite compound K. Pharmacol Res Perspect. 2016 Feb 10;4(1):e00215. doi:
10.1002/prp2.215. PMID: 26977303; PMCID: PMC4777267.

9: Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, Noguchi M, Watanabe T.
Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous
adrenomedullin in Crohn's disease rat model. J Gastroenterol. 2011
Oct;46(10):1187-96. doi: 10.1007/s00535-011-0438-2. Epub 2011 Aug 2. PMID:
21808981.

10: Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto
M, Yoshida M, Kono T, Jeong H, Chang EB. Daikenchuto (TU-100) alters murine
hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model:
effects of gender and withdrawal. Pharmacol Res Perspect. 2017 Oct;5(5):e00361.
doi: 10.1002/prp2.361. PMID: 28971602; PMCID: PMC5625165.