SCY-635

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125438

CAS#: 210759-10-7

Description: SCY-635 is a nonimmunosuppressive cyclosporine-based analog that exhibits potent suppression of hepatitis C virus (HCV) replication.

Chemical Structure

img
SCY-635
CAS# 210759-10-7
Instruction

Theoretical Analysis

MedKoo Cat#: 125438
Name: SCY-635
CAS#: 210759-10-7
Chemical Formula: C66H120N12O13S
Exact Mass: 1,320.88
Molecular Weight: 1,321.820
Elemental Analysis: C, 59.97; H, 9.15; N, 12.72; O, 15.73; S, 2.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SCY-635; 210759-10-7; SCY 635; WSU5343074; CHEMBL1269597

IUPAC/Chemical Name: (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-27-((2-(dimethylamino)ethyl)thio)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-24-(2-hydroxy-2-methylpropyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

InChi Key: AQHMBDAHQGYLIU-XNFHFXFQSA-N

InChi Code: InChI=1S/C66H120N12O13S/c1-27-29-30-42(13)53(79)52-57(83)69-45(28-2)59(85)78(26)65(92-32-31-71(18)19)64(90)75(23)49(36-66(16,17)91)56(82)70-50(40(9)10)62(88)72(20)46(33-37(3)4)55(81)67-43(14)54(80)68-44(15)58(84)73(21)47(34-38(5)6)60(86)74(22)48(35-39(7)8)61(87)76(24)51(41(11)12)63(89)77(52)25/h27,29,37-53,65,79,91H,28,30-36H2,1-26H3,(H,67,81)(H,68,80)(H,69,83)(H,70,82)/b29-27+/t42-,43+,44-,45+,46+,47+,48+,49+,50+,51+,52+,53-,65-/m1/s1

SMILES Code: CC[C@H]1C(=O)N([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)(C)O)C)SCCN(C)C)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,321.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hopkins S, Scorneaux B, Huang Z, Murray MG, Wring S, Smitley C, Harris R,
Erdmann F, Fischer G, Ribeill Y. SCY-635, a novel nonimmunosuppressive analog of
cyclosporine that exhibits potent inhibition of hepatitis C virus RNA
replication in vitro. Antimicrob Agents Chemother. 2010 Feb;54(2):660-72. doi:
10.1128/AAC.00660-09. Epub 2009 Nov 23. PMID: 19933795; PMCID: PMC2812147.

2: Hopkins S, Bobardt M, Chatterji U, Garcia-Rivera JA, Lim P, Gallay PA. The
cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A
complexes. Antimicrob Agents Chemother. 2012 Jul;56(7):3888-97. doi:
10.1128/AAC.00693-12. Epub 2012 May 14. PMID: 22585215; PMCID: PMC3393457.

3: Hopkins S, DiMassimo B, Rusnak P, Heuman D, Lalezari J, Sluder A, Scorneaux
B, Mosier S, Kowalczyk P, Ribeill Y, Baugh J, Gallay P. The cyclophilin
inhibitor SCY-635 suppresses viral replication and induces endogenous
interferons in patients with chronic HCV genotype 1 infection. J Hepatol. 2012
Jul;57(1):47-54. doi: 10.1016/j.jhep.2012.02.024. Epub 2012 Mar 13. PMID:
22425702.

4: Lee J. Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-
induced Hepatocellular Carcinoma. Korean J Physiol Pharmacol. 2013
Oct;17(5):375-83. doi: 10.4196/kjpp.2013.17.5.375. Epub 2013 Oct 17. PMID:
24227937; PMCID: PMC3823949.

5: Daito T, Watashi K, Sluder A, Ohashi H, Nakajima S, Borroto-Esoda K, Fujita
T, Wakita T. Cyclophilin inhibitors reduce phosphorylation of RNA-dependent
protein kinase to restore expression of IFN-stimulated genes in HCV-infected
cells. Gastroenterology. 2014 Aug;147(2):463-72. doi:
10.1053/j.gastro.2014.04.035. Epub 2014 Apr 29. PMID: 24786893.