BOF-4272

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125425

CAS#: 142181-44-0

Description: BOF-4272 is an OX inhibitor.

Chemical Structure

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BOF-4272
CAS# 142181-44-0
Instruction

Theoretical Analysis

MedKoo Cat#: 125425
Name: BOF-4272
CAS#: 142181-44-0
Chemical Formula: C18H13N4NaO3S
Exact Mass: 388.06
Molecular Weight: 388.380
Elemental Analysis: C, 55.67; H, 3.37; N, 14.43; Na, 5.92; O, 12.36; S, 8.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BOF4272; Bof-4272; Sodium-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo (1,5-a)-1,3,5-triazine-4-olate monohydrate; 142181-44-0; 2Q33D25ZXE

IUPAC/Chemical Name: sodium 8-(3-methoxy-4-(phenylsulfinyl)phenyl)pyrazolo[1,5-a][1,3,5]triazin-4-olate

InChi Key: OYINCFAELBUAIS-UHFFFAOYSA-M

InChi Code: InChI=1S/C18H14N4O3S.Na/c1-25-15-9-12(14-10-21-22-17(14)19-11-20-18(22)23)7-8-16(15)26(24)13-5-3-2-4-6-13;/h2-11H,1H3,(H,19,20,23);/q;+1/p-1

SMILES Code: COC1=C(S(C2=CC=CC=C2)=O)C=CC(C3=C4N=CN=C([O-])N4N=C3)=C1.[Na+]

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 388.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Naito S, Nishimura M. Biotransformation of the xanthine oxidase inhibitor
BOF-4272 and its metabolites in the liver and by the intestinal flora in rat.
Xenobiotica. 2000 Jan;30(1):103-9. doi: 10.1080/004982500237866. PMID: 10659955.

2: Naito S, Nishimura M, Jin Y. Biotransformation of BOF-4272, a sulfoxide-
containing drug, in the cynomolgus monkey. Eur J Drug Metab Pharmacokinet. 1999
Jul-Sep;24(3):279-86. doi: 10.1007/BF03190032. PMID: 10716068.

3: Naito S, Nishimura M, Yoshitsugu H, Nogawa H. Metabolic pathways and
pharmacokinetics of BOF-4272, a sulfoxide-containing drug, in the dog: in vivo
and in vitro studies. Biol Pharm Bull. 1999 Dec;22(12):1391-5. doi:
10.1248/bpb.22.1391. PMID: 10746178.

4: Naito S, Nishimura M, Nogawa H. Pharmacokinetics of BOF-4272, a xanthine
oxidase inhibitor, after single intravenous or oral administration to male mice
and rats. J Pharm Pharmacol. 1999 Mar;51(3):347-51. doi:
10.1211/0022357991772358. PMID: 10344637.

5: Yamamoto T, Moriwaki Y, Suda M, Nasako Y, Takahashi S, Hiroishi K, Nakano T,
Hada T, Higashino K. Effect of BOF-4272 on the oxidation of allopurinol and
pyrazinamide in vivo. Is xanthine dehydrogenase or aldehyde oxidase more
important in oxidizing both allopurinol and pyrazinamide? Biochem Pharmacol.
1993 Dec 14;46(12):2277-84. doi: 10.1016/0006-2952(93)90618-7. PMID: 8274161.

6: Naito S, Nishimura M. Enantioselective uptake of BOF-4272, a xanthine oxidase
inhibitor with a chiral sulfoxide, by isolated rat hepatocytes. Yakugaku Zasshi.
2001 Dec;121(12):989-94. doi: 10.1248/yakushi.121.989. PMID: 11766411.

7: Naito S, Nishimura M. Stereoselective pharmacokinetics of BOF-4272 racemate
after oral administration to rats and dogs. Biol Pharm Bull. 2002
May;25(5):674-7. doi: 10.1248/bpb.25.674. PMID: 12033515.

8: Naito S, Nishimura M, Tamao Y. Evaluation of the pharmacological actions and
pharmacokinetics of BOF-4272, a xanthine oxidase inhibitor, in mouse liver. J
Pharm Pharmacol. 2000 Feb;52(2):173-9. doi: 10.1211/0022357001773823. PMID:
10714947.

9: Shibukawa A, Kadohara M, He JY, Nishimura M, Naito S, Nakagawa T. Study of
the enantioselective binding between BOF-4272 and serum albumins by means of
high-performance frontal analysis. J Chromatogr A. 1995 Mar 3;694(1):81-9. doi:
10.1016/0021-9673(94)00653-q. Erratum in: J Chromatogr A 1995 Aug 4;708(2):364.
PMID: 7719472.

10: Uematsu T, Nakashima M. Pharmacokinetic and pharmacodynamic properties of a
novel xanthine oxidase inhibitor, BOF-4272, in healthy volunteers. J Pharmacol
Exp Ther. 1994 Aug;270(2):453-9. PMID: 8071837.