COH1 inhibitor
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125386

CAS#: 20217-22-5

Description: COH1 is a ribonucleotide reductase (RR) inhibitor.

Chemical Structure

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COH1 inhibitor
CAS# 20217-22-5
Instruction

Theoretical Analysis

MedKoo Cat#: 125386
Name: COH1 inhibitor
CAS#: 20217-22-5
Chemical Formula: C11H10N2O3S
Exact Mass: 250.04
Molecular Weight: 250.270
Elemental Analysis: C, 52.79; H, 4.03; N, 11.19; O, 19.18; S, 12.81

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 5650 2 Weeks
Bulk inquiry

Synonym: COH1 inhibitor; COH-1 inhibitor; COH 1 inhibitor; COH-1; COH1;

IUPAC/Chemical Name: N-(4-(3,4-dihydroxyphenyl)thiazol-2-yl)acetamide

InChi Key: URUUPFDMCFXHGD-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H10N2O3S/c1-6(14)12-11-13-8(5-17-11)7-2-3-9(15)10(16)4-7/h2-5,15-16H,1H3,(H,12,13,14)

SMILES Code: O=C(C)NC1=NC(C2=CC(O)=C(O)C=C2)=CS1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 250.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ohtsuka H, Kawai S, Otsubo Y, Shimasaki T, Yamashita A, Aiba H. Metarhizium
robertsii COH1 functionally complements Schizosaccharomyces pombe Ecl family
proteins. J Gen Appl Microbiol. 2023 Oct 6. doi: 10.2323/jgam.2023.09.001. Epub
ahead of print. PMID: 37813640.

2: Seifert W, Kühnisch J, Maritzen T, Lommatzsch S, Hennies HC, Bachmann S, Horn
D, Haucke V. Cohen syndrome-associated protein COH1 physically and functionally
interacts with the small GTPase RAB6 at the Golgi complex and directs neurite
outgrowth. J Biol Chem. 2015 Feb 6;290(6):3349-58. doi: 10.1074/jbc.M114.608174.
Epub 2014 Dec 9. PMID: 25492866; PMCID: PMC4319006.

3: Seifert W, Kühnisch J, Maritzen T, Horn D, Haucke V, Hennies HC. Cohen
syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein
required for Golgi integrity. J Biol Chem. 2011 Oct 28;286(43):37665-75. doi:
10.1074/jbc.M111.267971. Epub 2011 Aug 24. PMID: 21865173; PMCID: PMC3199510.

4: Athanasakis E, Fabretto A, Faletra F, Mocenigo M, Morgan A, Gasparini P. Two
Novel COH1 Mutations in an Italian Patient with Cohen Syndrome. Mol Syndromol.
2012 Jun;3(1):30-33. doi: 10.1159/000338816. Epub 2012 May 16. PMID: 22855652;
PMCID: PMC3398820.

5: Kondo I, Shimizu A, Asakawa S, Miyamoto K, Yamagata H, Tabara Y, Shimizu N.
COH1 analysis and linkage study in two Japanese families with Cohen syndrome.
Clin Genet. 2005 Mar;67(3):270-2. doi: 10.1111/j.1399-0004.2005.00396.x. PMID:
15691367.

6: Parri V, Katzaki E, Uliana V, Scionti F, Tita R, Artuso R, Longo I, Boschloo
R, Vijzelaar R, Selicorni A, Brancati F, Dallapiccola B, Zelante L, Hamel CP,
Sarda P, Lalani SR, Grasso R, Buoni S, Hayek J, Servais L, de Vries BB,
Georgoudi N, Nakou S, Petersen MB, Mari F, Renieri A, Ariani F. High frequency
of COH1 intragenic deletions and duplications detected by MLPA in patients with
Cohen syndrome. Eur J Hum Genet. 2010 Oct;18(10):1133-40. doi:
10.1038/ejhg.2010.59. Epub 2010 May 12. PMID: 20461111; PMCID: PMC2987453.

7: Seifert W, Holder-Espinasse M, Spranger S, Hoeltzenbein M, Rossier E, Dollfus
H, Lacombe D, Verloes A, Chrzanowska KH, Maegawa GH, Chitayat D, Kotzot D, Huhle
D, Meinecke P, Albrecht B, Mathijssen I, Leheup B, Raile K, Hennies HC, Horn D.
Mutational spectrum of COH1 and clinical heterogeneity in Cohen syndrome. J Med
Genet. 2006 May;43(5):e22. doi: 10.1136/jmg.2005.039867. PMID: 16648375; PMCID:
PMC2564527.