Fluorthanatrace F-18

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125327

CAS#: 1567375-87-4

Description: Fluorine F 18 Fluorthanatrace is a radiotracer.

Chemical Structure

img
Fluorthanatrace F-18
CAS# 1567375-87-4
Instruction

Theoretical Analysis

MedKoo Cat#: 125327
Name: Fluorthanatrace F-18
CAS#: 1567375-87-4
Chemical Formula: C18H1618FN3O2
Exact Mass: 324.13
Molecular Weight: 324.350
Elemental Analysis: C, 66.66; H, 4.97; F, 5.55; N, 12.96; O, 9.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Fluorthanatrace F-18; Fluorine F 18 fluorthanatrace; 9B8U3WZ84W; UNII-9B8U3WZ84W; 1567375-87-4

IUPAC/Chemical Name: 1-(4-(2-(fluoro-18F)ethoxy)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one

InChi Key: DUYPGBKQTGXZRE-AWDFDDCISA-N

InChi Code: InChI=1S/C18H16FN3O2/c19-8-11-24-13-6-4-12(5-7-13)17-21-15-3-1-2-14-16(15)22(17)10-9-20-18(14)23/h1-7H,8-11H2,(H,20,23)/i19-1

SMILES Code: [18F]CCOC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Lee HS, Schwarz SW, Schubert EK, Chen DL, Doot RK, Makvandi M, Lin LL,
McDonald ES, Mankoff DA, Mach RH. The Development of 18F
Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1.
Radiol Imaging Cancer. 2022 Jan;4(1):e210070. doi: 10.1148/rycan.210070. PMID:
35089089; PMCID: PMC8830434.

2: Pantel AR, Gitto SB, Makvandi M, Kim H, Medvedv S, Weeks JK, Torigian DA,
Hsieh CJ, Ferman B, Latif NA, Tanyi JL, Martin LP, Lanzo SM, Liu F, Cao Q, Mills
GB, Doot RK, Mankoff DA, Mach RH, Lin LL, Simpkins F. [18F]FluorThanatrace
([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker
of Response in Ovarian Cancer, a Pilot Study. Clin Cancer Res. 2023 Apr
14;29(8):1515-1527. doi: 10.1158/1078-0432.CCR-22-1602. PMID: 36441795.

3: Edmonds CE, Makvandi M, Lieberman BP, Xu K, Zeng C, Li S, Hou C, Lee H,
Greenberg RA, Mankoff DA, Mach RH. [(18)F]FluorThanatrace uptake as a marker of
PARP1 expression and activity in breast cancer. Am J Nucl Med Mol Imaging. 2016
Jan 28;6(1):94-101. PMID: 27069769; PMCID: PMC4749508.

4: Young AJ, Pantel AR, Viswanath V, Dominguez TL, Makvandi M, Lee H, Li S,
Schubert EK, Pryma DA, Farwell MD, Mach RH, Simpkins F, Lin LL, Mankoff DA, Doot
RK. Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose)
Polymerase-1-Targeted 18F-Fluorthanatrace PET Images of Ovarian
Cancer. J Nucl Med. 2022 Jan;63(1):44-50. doi: 10.2967/jnumed.121.261894. Epub
2021 Apr 16. PMID: 33863820; PMCID: PMC8717190.

5: Surasi DSS, Lin L, Ravizzini G, Wong F. Supraclavicular and Axillary
Lymphadenopathy Induced by COVID-19 Vaccination on 18F-Fluorthanatrace, 68Ga-
DOTATATE, and 18F-Fluciclovine PET/CT. Clin Nucl Med. 2022 Feb 1;47(2):195-196.
doi: 10.1097/RLU.0000000000003891. PMID: 34507331.