MK-6325

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125245

CAS#: 1263814-52-3

Description: MK-6325 is a potent HCV NS3/4A protease inhibitor.

Chemical Structure

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MK-6325
CAS# 1263814-52-3
Instruction

Theoretical Analysis

MedKoo Cat#: 125245
Name: MK-6325
CAS#: 1263814-52-3
Chemical Formula: C42H56N6O9S
Exact Mass: 820.38
Molecular Weight: 821.000
Elemental Analysis: C, 61.44; H, 6.88; N, 10.24; O, 17.54; S, 3.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MK-6325; MK 6325; CHEMBL4297304; 59LD48P07K; DB15249

IUPAC/Chemical Name: (3R,20R,24R,28S,34E,36S,38R,41S)-9-methoxy-N-(1-methylcyclopropyl)sulfonyl-26,40,42-trioxo-4,25-dioxa-1,6,13,27,39-pentazaheptacyclo[26.13.1.13,41.05,14.07,12.020,24.036,38]tritetraconta-5,7(12),8,10,13,34-hexaene-38-carboxamide

InChi Key: BLFKRFGLQFYXDF-WAZRELCSSA-N

InChi Code: InChI=1S/C42H56N6O9S/c1-41(20-21-41)58(53,54)47-39(51)42-24-27(42)14-8-4-3-5-9-16-32-38(50)48-25-29(23-34(48)36(49)46-42)56-37-31(43-30-19-18-28(55-2)22-33(30)44-37)15-10-6-7-12-26-13-11-17-35(26)57-40(52)45-32/h8,14,18-19,22,26-27,29,32,34-35H,3-7,9-13,15-17,20-21,23-25H2,1-2H3,(H,45,52)(H,46,49)(H,47,51)/b14-8+/t26-,27-,29-,32+,34+,35-,42-/m1/s1

SMILES Code: O=C([C@@]1(N2)C[C@@]1([H])/C=C/CCCCC[C@]3([H])NC(O[C@]4([H])CCC[C@@]4([H])CCCCCC5=NC6=C(C=C(OC)C=C6)N=C5O[C@@]7([H])CN(C3=O)[C@](C7)([H])C2=O)=O)NS(=O)(C8(C)CC8)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 821.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rudd MT, Butcher JW, Nguyen KT, McIntyre CJ, Romano JJ, Gilbert KF, Bush KJ,
Liverton NJ, Holloway MK, Harper S, Ferrara M, DiFilippo M, Summa V, Swestock J,
Fritzen J, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q,
McClain S, McHale C, Stahlhut MW, Black S, Chase R, Soriano A, Fandozzi CM,
Taylor A, Trainor N, Olsen DB, Coleman PJ, Ludmerer SW, McCauley JA.
P2-quinazolinones and bis-macrocycles as new templates for next-generation
hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
ChemMedChem. 2015 Apr;10(4):727-35. doi: 10.1002/cmdc.201402558. Epub 2015 Mar
10. PMID: 25759009.

2: Li H, Scott JP, Chen CY, Journet M, Belyk K, Balsells J, Kosjek B, Baxter CA,
Stewart GW, Wise C, Alam M, Song ZJ, Tan L. Synthesis of bis-macrocyclic HCV
protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling
and ring closing metathesis. Org Lett. 2015 Mar 20;17(6):1533-6. doi:
10.1021/acs.orglett.5b00418. Epub 2015 Mar 10. PMID: 25754231.