SN29176

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125201

CAS#: N/A

Description: SN29176 is a Hypoxia/GDEPT Prodrug.

Chemical Structure

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SN29176
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 125201
Name: SN29176
CAS#: N/A
Chemical Formula: C14H19Br2N3O6S
Exact Mass: 514.94
Molecular Weight: 517.190
Elemental Analysis: C, 32.51; H, 3.70; Br, 30.90; N, 8.12; O, 18.56; S, 6.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SN29176; SN-29176; SN 29176

IUPAC/Chemical Name: 5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-4-(methylsulfonyl)-2-nitrobenzamide

InChi Key: RWHLJEPQZVSJIM-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19Br2N3O6S/c1-26(24,25)13-9-11(19(22)23)10(14(21)17-4-7-20)8-12(13)18(5-2-15)6-3-16/h8-9,20H,2-7H2,1H3,(H,17,21)

SMILES Code: BrCCN(CCBr)C1=CC(C(NCCO)=O)=C([N+]([O-])=O)C=C1S(C)(=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 517.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ashoorzadeh A, Mowday AM, Guise CP, Silva S, Bull MR, Abbattista MR, Copp JN,
Williams EM, Ackerley DF, Patterson AV, Smaill JB. Interrogation of the
Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series
Designed for Cancer Gene Therapy Applications. Pharmaceuticals (Basel). 2022 Feb
1;15(2):185. doi: 10.3390/ph15020185. PMID: 35215297; PMCID: PMC8877822.

2: Abbattista MR, Ashoorzadeh A, Guise CP, Mowday AM, Mittra R, Silva S, Hicks
KO, Bull MR, Jackson-Patel V, Lin X, Prosser GA, Lambie NK, Dachs GU, Ackerley
DF, Smaill JB, Patterson AV. Restoring Tumour Selectivity of the Bioreductive
Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by
Human Aldo-Keto Reductase 1C3. Pharmaceuticals (Basel). 2021 Nov 26;14(12):1231.
doi: 10.3390/ph14121231. PMID: 34959631; PMCID: PMC8707548.