Altanserin F-18

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 124897

CAS#: 139418-52-3

Description: Altanserin F-18is a 5-hydroxytryptamine type 2a receptor (5-HT2AR) radiotracer.

Chemical Structure

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Altanserin F-18
CAS# 139418-52-3
Instruction

Theoretical Analysis

MedKoo Cat#: 124897
Name: Altanserin F-18
CAS#: 139418-52-3
Chemical Formula: C22H2218FN3O2S
Exact Mass: 410.14
Molecular Weight: 410.500
Elemental Analysis: C, 64.37; H, 5.40; F, 4.39; N, 10.24; O, 7.79; S, 7.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: [18F]Altanserin; (18F)Altanserin; Altanserin F-18; Fluorine-18 altanserin; 6GVX9S46ZO

IUPAC/Chemical Name: 3-(2-(4-(4-(fluoro-18F)benzoyl)piperidin-1-yl)ethyl)-2-mercaptoquinazolin-4(3H)-one

InChi Key: SMYALUSCZJXWHG-VNRZBHCFSA-N

InChi Code: InChI=1S/C22H22FN3O2S/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)/i23-1

SMILES Code: [18F]C1=CC=C(C(C2CCN(CCN3C(C4=CC=CC=C4N=C3S)=O)CC2)=O)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pinborg LH, Adams KH, Yndgaard S, Hasselbalch SG, Holm S, Kristiansen H,
Paulson OB, Knudsen GM. [18F]altanserin binding to human 5HT2A receptors is
unaltered after citalopram and pindolol challenge. J Cereb Blood Flow Metab.
2004 Sep;24(9):1037-45. doi: 10.1097/01.WCB.0000126233.08565.E7. PMID: 15356424.

2: Kroll T, Elmenhorst D, Matusch A, Celik AA, Wedekind F, Weisshaupt A, Beer S,
Bauer A. [¹⁸F]Altanserin and small animal PET: impact of multidrug efflux
transporters on ligand brain uptake and subsequent quantification of 5-HT₂A
receptor densities in the rat brain. Nucl Med Biol. 2014 Jan;41(1):1-9. doi:
10.1016/j.nucmedbio.2013.09.001. Epub 2013 Oct 9. PMID: 24120220.

3: Hasler F, Kuznetsova OF, Krasikova RN, Cservenyak T, Quednow BB, Vollenweider
FX, Ametamey SM, Westera G. GMP-compliant radiosynthesis of [18F]altanserin and
human plasma metabolite studies. Appl Radiat Isot. 2009 Apr;67(4):598-601. doi:
10.1016/j.apradiso.2008.12.007. Epub 2008 Dec 24. PMID: 19162492.

4: Kroll T, Elmenhorst D, Matusch A, Wedekind F, Weisshaupt A, Beer S, Bauer A.
Suitability of [18F]altanserin and PET to determine 5-HT2A receptor availability
in the rat brain: in vivo and in vitro validation of invasive and non-invasive
kinetic models. Mol Imaging Biol. 2013 Aug;15(4):456-67. doi:
10.1007/s11307-013-0621-3. Epub 2013 Mar 1. PMID: 23456885.

5: Ungersboeck J, Richter S, Collier L, Mitterhauser M, Karanikas G,
Lanzenberger R, Dudczak R, Wadsak W. Radiolabeling of [18F]altanserin - a
microfluidic approach. Nucl Med Biol. 2012 Oct;39(7):1087-92. doi:
10.1016/j.nucmedbio.2012.04.004. Epub 2012 May 23. PMID: 22633218.

6: Smith GS, Price JC, Lopresti BJ, Huang Y, Simpson N, Holt D, Mason NS,
Meltzer CC, Sweet RA, Nichols T, Sashin D, Mathis CA. Test-retest variability of
serotonin 5-HT2A receptor binding measured with positron emission tomography and
[18F]altanserin in the human brain. Synapse. 1998 Dec;30(4):380-92. doi:
10.1002/(SICI)1098-2396(199812)30:4<380::AID-SYN5>3.0.CO;2-U. PMID: 9826230.