SSE1806

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MedKoo CAT#: 124880

CAS#: N/A

Description: SSE1806 is a Microtubule Destabilizer That Overcomes Multidrug Resistance. SSE1806 exhibited the most potent antiproliferative activity with GI50 values ranging from 1.29 ± 0.01 to 21.15 ± 2.1 μM in cancer cell lines of different origins; it directly inhibited microtubule polymerization, causing aberrant mitosis and G2/M arrest. Prolonged treatment with SSE1806 increased p53 expression, induced cell death in monolayer cultures, and reduced the growth of mouse- and patient-derived human colon cancer organoids. Importantly, SSE1806 overcame multidrug resistance in a cell line overexpressing MDR-1

Chemical Structure

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SSE1806
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 124880
Name: SSE1806
CAS#: N/A
Chemical Formula: C21H18N2O5
Exact Mass: 378.12
Molecular Weight: 378.380
Elemental Analysis: C, 66.66; H, 4.80; N, 7.40; O, 21.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SSE1806; SSE 1806; SSE-1806

IUPAC/Chemical Name: 11-(3-nitrophenyl)-2,3,7,8,9,11-hexahydro-[1,4]dioxino[2,3-b]acridin-10(6H)-one

InChi Key: QIBBEPCCDJOQSF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H18N2O5/c24-17-6-2-5-15-21(17)20(12-3-1-4-13(9-12)23(25)26)14-10-18-19(11-16(14)22-15)28-8-7-27-18/h1,3-4,9-11,20,22H,2,5-8H2

SMILES Code: O=C(CCC1)C2=C1NC3=CC(OCCO4)=C4C=C3C2C5=CC([N+]([O-])=O)=CC=C5

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 378.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance
Farhat Firdous, Sharon Riaz, Muhammad Furqan, Salman Fozail, Khushboo Fatima, Sebastian Öther-Gee Pohl, Nora Julia Doleschall, Kevin B. Myant, Jordan Kahfi, Abdul-Hamid Emwas, Mariusz Jaremko, Ghayoor Abbas Chotana, Rahman Shah Zaib Saleem, and Amir Faisal
ACS Medicinal Chemistry Letters Article ASAP
DOI: 10.1021/acsmedchemlett.3c00258