Flufylline

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MedKoo CAT#: 124725

CAS#: 82190-91-8

Description: FLUFYLLINE, a theophylline derivative, has a long-lasting blood pressure lowering activity as well as remarkable serotonin- and histamine antagonism and broncholytic activity.

Chemical Structure

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Flufylline
CAS# 82190-91-8
Instruction

Theoretical Analysis

MedKoo Cat#: 124725
Name: Flufylline
CAS#: 82190-91-8
Chemical Formula: C21H24FN5O3
Exact Mass: 413.19
Molecular Weight: 413.450
Elemental Analysis: C, 61.01; H, 5.85; F, 4.60; N, 16.94; O, 11.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Flufylline; Flufyllin; 82190-91-8; Flufylline [INN]; Flufilina [Spanish];

IUPAC/Chemical Name: 7-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1,3-dimethylpurine-2,6-dione

InChi Key: PMEYQPKJAPXGPS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H24FN5O3/c1-24-19-17(20(29)25(2)21(24)30)27(13-23-19)12-11-26-9-7-15(8-10-26)18(28)14-3-5-16(22)6-4-14/h3-6,13,15H,7-12H2,1-2H3

SMILES Code: O=C(N1C)N(C)C2=C(N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C=N2)C1=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Korstanje C, Sprenkels R, Doods HN, Hugtenburg JG, Boddeke E, Batink HD,
Thoolen MJ, Van Zwieten PA. Characterization of flufylline, fluprofylline,
ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and
5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and
5-HT2-receptors: comparison with ketanserin. J Pharm Pharmacol. 1986
May;38(5):374-9. doi: 10.1111/j.2042-7158.1986.tb04590.x. PMID: 2872314.

2: Thiele K, Jahn U, Geissmann F, Zirngibl L. Neue biologisch aktive
Theophyllin-Derivate. Synthese und pharmakologische Eigenschaften von Flufyllin
und Fluprofyllin [New biologically active theophylline derivatives. Synthesis
and pharmacologic properties of flufylline and fluprofylline].
Arzneimittelforschung. 1984;34(1):1-4. German. PMID: 6608355.