SH491

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MedKoo CAT#: 124681

CAS#: N/A

Description: SH491 is a potent antiosteoporosis Agent. SH491 (IC50 = 11.8 nM) showed the high potency with 100% inhibition at 0.1 μM and 44.4% inhibition at an even lower concentration of 0.01 μM, which was much more potent than the lead compound PPD (IC50 = 10.3 μM). SH491 also exhibited a notable impact on the osteoblastogenesis of MC3T3-E1 preosteoblasts. SH491 inhibits the expression of osteoclastogenesis-related marker genes and proteins, including TRAP, CTSK, MMP-9, and ATPase v0d2. In vivo, SH491 could dramatically decrease the ovariectomy-induced osteoclast activity and relieve osteoporosis obviously.

Chemical Structure

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SH491
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 124681
Name: SH491
CAS#: N/A
Chemical Formula: C33H50N2O
Exact Mass: 490.39
Molecular Weight: 490.780
Elemental Analysis: C, 80.76; H, 10.27; N, 5.71; O, 3.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SH491; SH-491; SH 491

IUPAC/Chemical Name: (1S,3aR,3bR,5aR,11aR,11bR,13R,13aR)-3a,3b,6,6,8,11a-hexamethyl-1-(6-methylhepta-1,5-dien-2-yl)-2,3,3a,3b,4,5,5a,6,11,11a,11b,12,13,13a-tetradecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinazolin-13-ol

InChi Key: SDNYORIEEOHMNL-WZNPBPMFSA-N

InChi Code: InChI=1S/C33H50N2O/c1-20(2)11-10-12-21(3)24-13-15-33(9)28(24)25(36)17-27-31(7)18-23-19-34-22(4)35-29(23)30(5,6)26(31)14-16-32(27,33)8/h11,19,24-28,36H,3,10,12-18H2,1-2,4-9H3/t24-,25-,26+,27-,28+,31+,32-,33-/m1/s1

SMILES Code: C/C(C)=C\CCC([C@H]1CC[C@@]2(C)[C@]([C@]3([H])C[C@@H](O)[C@@]21[H])(C)CC[C@@]([C@]3(C)C4)([H])C(C)(C)C5=C4C=NC(C)=N5)=C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 490.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Wang SJ, Zhang J, Zhang JZ, Ning RN, Li CC, Xu X, Jiang M, Qiu WW. Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S)-Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents. J Med Chem. 2023 Aug 19. doi: 10.1021/acs.jmedchem.3c00601. Epub ahead of print. PMID: 37597216.