SOD1-Derlin-1 inhibitor 56-59
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 123952

CAS#: 2170170-27-9

Description: SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction.

Chemical Structure

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SOD1-Derlin-1 inhibitor 56-59
CAS# 2170170-27-9
Instruction

Theoretical Analysis

MedKoo Cat#: 123952
Name: SOD1-Derlin-1 inhibitor 56-59
CAS#: 2170170-27-9
Chemical Formula: C22H18N4OS
Exact Mass: 386.12
Molecular Weight: 386.470
Elemental Analysis: C, 68.37; H, 4.69; N, 14.50; O, 4.14; S, 8.30

Price and Availability

Size Price Availability Quantity
100mg USD 1350 2 Weeks
200mg USD 2350 2 Weeks
500mg USD 3650 2 Weeks
1g USD 5650 2 Weeks
2g USD 8650 2 Weeks
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Synonym: SOD1-Derlin-1 inhibitor 56-59; SOD1-Derlin-1 inhibitor-2; 2170170-27-9; SCHEMBL19737511; EX-A7213;

IUPAC/Chemical Name: 3-amino-N-phenyl-N-prop-2-enyl-6-pyridin-3-ylthieno[2,3-b]pyridine-2-carboxamide

InChi Key: NQWFEZIEBLGBMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18N4OS/c1-2-13-26(16-8-4-3-5-9-16)22(27)20-19(23)17-10-11-18(25-21(17)28-20)15-7-6-12-24-14-15/h2-12,14H,1,13,23H2

SMILES Code: O=C(C1=C(N)C2=CC=C(C3=CC=CN=C3)N=C2S1)N(C4=CC=CC=C4)CC=C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 386.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. doi: 10.1038/s41467-018-05127-2. PMID: 29991716; PMCID: PMC6039432.