MDG506

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130593

CAS#: 933005-54-0

Description: MDG506 is a novel selective disruptor of AR interaction, MDG506 demonstrates low cellular toxicity in PCa models and dose responsive reduction of classical antiandrogen-induced prostate specific antigen expression.

Chemical Structure

img
MDG506
CAS# 933005-54-0
Instruction

Theoretical Analysis

MedKoo Cat#: 130593
Name: MDG506
CAS#: 933005-54-0
Chemical Formula: C22H18N2O5
Exact Mass: 390.12
Molecular Weight: 390.400
Elemental Analysis: C, 67.69; H, 4.65; N, 7.18; O, 20.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MDG 506, MDG-506

IUPAC/Chemical Name: (E)-N'-(4-Hydroxy-3,5-dimethoxybenzylidene)naphtho[2,1-b]furan-2-carbohydrazide

InChi Key: ICEFORRNJVZCHJ-FSJBWODESA-N

InChi Code: InChI=1S/C22H18N2O5/c1-27-18-9-13(10-19(28-2)21(18)25)12-23-24-22(26)20-11-16-15-6-4-3-5-14(15)7-8-17(16)29-20/h3-12,25H,1-2H3,(H,24,26)/b23-12+

SMILES Code: O=C(C1=CC2=C3C=CC=CC3=CC=C2O1)N/N=C/C4=CC(OC)=C(O)C(OC)=C4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 390.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Caboni L, Kinsella GK, Blanco F, Fayne D, Jagoe WN, Carr M, Williams DC, Meegan MJ, Lloyd DG. "True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer. J Med Chem. 2012 Feb 23;55(4):1635-44. doi: 10.1021/jm201438f. Epub 2012 Feb 10. PMID: 22280402; PMCID: PMC3295204.