I-287

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130581

CAS#: 2014368-93-3

Description: I-287 is a novel, potent, and selective oral inhibitor of PAR2. It inhibits PAR2-mediated activation of Gαq and Gα12/13 (IC50=45-390 nM).

Chemical Structure

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I-287
CAS# 2014368-93-3
Instruction

Theoretical Analysis

MedKoo Cat#: 130581
Name: I-287
CAS#: 2014368-93-3
Chemical Formula: C30H30ClFN4O4
Exact Mass: 564.19
Molecular Weight: 565.040
Elemental Analysis: C, 63.77; H, 5.35; Cl, 6.27; F, 3.36; N, 9.92; O, 11.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: I 287, I287

IUPAC/Chemical Name: 6-[4-[[5-(4-Chloro-3-fluorophenyl)-7-(1,1-dimethylethyl)furo[3,2-b]pyridin-2-yl]carbonyl]-3,3-dimethyl-1-piperazinyl]-3-pyridinecarboxylic acid

InChi Key: WPJYZCYPCSYODL-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H30ClFN4O4/c1-29(2,3)19-13-22(17-6-8-20(31)21(32)12-17)34-23-14-24(40-26(19)23)27(37)36-11-10-35(16-30(36,4)5)25-9-7-18(15-33-25)28(38)39/h6-9,12-15H,10-11,16H2,1-5H3,(H,38,39)

SMILES Code: O=C(C1=CC=C(N2CC(C)(C)N(C(C3=CC4=NC(C5=CC=C(Cl)C(F)=C5)=CC(C(C)(C)C)=C4O3)=O)CC2)N=C1)O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 565.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Avet C, Sturino C, Grastilleur S, Gouill CL, Semache M, Gross F, Gendron L, Bennani Y, Mancini JA, Sayegh CE, Bouvier M. The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects. Commun Biol. 2020 Nov 27;3(1):719. doi: 10.1038/s42003-020-01453-8. PMID: 33247181; PMCID: PMC7695697.