Mosnodenvir
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MedKoo CAT#: 130537

CAS#: 2043343-94-6

Description: Mosnodenvir, also known as JNJ-1802, is an oral, first-in-class DENV (NS3-NS4B) inhibitor. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Viral RNA suppression to below the limit of detection was achieved at concentrations of >1.6 nM, with a median concentration exhibiting 50% of maximal inhibitory effect (IC50) of 1.23x10-02 nM and 1.28x10-02 nM for the DENV-2/RL and DENV-2/16681 strains, respectively. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice.

Chemical Structure

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Mosnodenvir
CAS# 2043343-94-6
Instruction

Theoretical Analysis

MedKoo Cat#: 130537
Name: Mosnodenvir
CAS#: 2043343-94-6
Chemical Formula: C26H22ClF3N2O6S
Exact Mass: 582.08
Molecular Weight: 582.980
Elemental Analysis: C, 53.57; H, 3.80; Cl, 6.08; F, 9.78; N, 4.81; O, 16.47; S, 5.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ 1802, JNJ1802, JNJ-64281802, JNJ 64281802, JNJ64281802; Mosnodenvir;

IUPAC/Chemical Name: (+)-2-(4-Chloro-2-methoxyphenyl)-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1-(5-(trifluoromethoxy)-1H-indol-3-yl)ethan-1-one

InChi Key: QNOPDDHSGQQLCV-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H22ClF3N2O6S/c1-36-17-9-15(10-18(11-17)39(3,34)35)32-24(19-6-4-14(27)8-23(19)37-2)25(33)21-13-31-22-7-5-16(12-20(21)22)38-26(28,29)30/h4-13,24,31-32H,1-3H3

SMILES Code: O=C(C1=CNC2=C1C=C(OC(F)(F)F)C=C2)C(C3=CC=C(Cl)C=C3OC)NC4=CC(S(=O)(C)=O)=CC(OC)=C4

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 582.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ackaert O, Vanhoutte F, Verpoorten N, Buelens A, Lachau-Durand S, Lammens L, Hoetelmans R, Van Loock M, Herrera-Taracena G. Safety, tolerability and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a Phase 1, double-blind, randomized, dose-escalation study in healthy volunteers. Clin Infect Dis. 2023 May 10:ciad284. doi: 10.1093/cid/ciad284. Epub ahead of print. PMID: 37161721.

2. Goethals O, Kaptein SJF, Kesteleyn B, Bonfanti JF, Van Wesenbeeck L, Bardiot D, Verschoor EJ, Verstrepen BE, Fagrouch Z, Putnak JR, Kiemel D, Ackaert O, Straetemans R, Lachau-Durand S, Geluykens P, Crabbe M, Thys K, Stoops B, Lenz O, Tambuyzer L, De Meyer S, Dallmeier K, McCracken MK, Gromowski GD, Rutvisuttinunt W, Jarman RG, Karasavvas N, Touret F, Querat G, de Lamballerie X, Chatel-Chaix L, Milligan GN, Beasley DWC, Bourne N, Barrett ADT, Marchand A, Jonckers THM, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Bogers WM, Neyts J, Van Loock M. Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates. Nature. 2023 Mar;615(7953):678-686. doi: 10.1038/s41586-023-05790-6. Epub 2023 Mar 15. PMID: 36922586; PMCID: PMC10033419.

3. Goethals O, Voge NV, Kesteleyn B, Chaltin P, Jinks T, De Marez T, Koul A, Draghia-Akli R, Neyts J, Van Loock M. A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships. Antiviral Res. 2023 Feb;210:105495. doi: 10.1016/j.antiviral.2022.105495. Epub 2022 Dec 22. PMID: 36567021; PMCID: PMC9902276.