10-Bromodecanoic acid | CAS#50530-12-6 | synthesis

10-Bromodecanoic acid
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130337

CAS#: 50530-12-6

Description: 10-Bromodecanoic acid is used in the preparation of alkylcarboxylate-grafted polyethylenimine, serving as an alkylcarboxylate chain source.

Chemical Structure

10-Bromodecanoic acid

CAS# 50530-12-6

Instruction

Theoretical Analysis

MedKoo Cat#: 130337
Name: 10-Bromodecanoic acid
CAS#: 50530-12-6
Chemical Formula: C10H19BrO2
Exact Mass: 250.06
Molecular Weight: 251.160
Elemental Analysis: C, 47.82; H, 7.63; Br, 31.81; O, 12.74

Price and Availability

Size	Price	Availability
5g	USD 280	2 Weeks
25g	USD 507	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 10-Bromodecanoic acid

IUPAC/Chemical Name: 10-bromodecanoic acid

InChi Key: PGVRSPIEZYGOAD-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H19BrO2/c11-9-7-5-3-1-2-4-6-8-10(12)13/h1-9H2,(H,12,13)

SMILES Code: OC(CCCCCCCCCBr)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 251.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Scheel RA, Ho T, Kageyama Y, Masisak J, McKenney S, Lundgren BR, Nomura CT. Optimizing a Fed-Batch High-Density Fermentation Process for Medium Chain-Length Poly(3-Hydroxyalkanoates) in Escherichia coli. Front Bioeng Biotechnol. 2021 Feb 26;9:618259. doi: 10.3389/fbioe.2021.618259. PMID: 33718339; PMCID: PMC7953831.

2: Ayatollahi S, Salmasi Z, Hashemi M, Askarian S, Oskuee RK, Abnous K, Ramezani M. Aptamer-targeted delivery of Bcl-xL shRNA using alkyl modified PAMAM dendrimers into lung cancer cells. Int J Biochem Cell Biol. 2017 Nov;92:210-217. doi: 10.1016/j.biocel.2017.10.005. Epub 2017 Oct 12. PMID: 29031805.

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4: Ebrahimian M, Taghavi S, Ghoreishi M, Sedghi S, Amel Farzad S, Ramezani M, Hashemi M. Evaluation of Efficiency of Modified Polypropylenimine (PPI) with Alkyl Chains as Non-viral Vectors Used in Co-delivery of Doxorubicin and TRAIL Plasmid. AAPS PharmSciTech. 2018 Apr;19(3):1029-1036. doi: 10.1208/s12249-017-0913-z. Epub 2017 Nov 7. PMID: 29116619.

5: Ariaee FM, Hashemi M, Farzad SA, Abnous K, Ramezani M. Alkyl cross-linked low molecular weight polypropyleneimine dendrimers as efficient gene delivery vectors. Iran J Basic Med Sci. 2016 Oct;19(10):1096-1104. PMID: 27872706; PMCID: PMC5110658.

6: Azimifar MA, Salmasi Z, Doosti A, Babaei N, Hashemi M. Evaluation of the efficiency of modified PAMAM dendrimer with low molecular weight protamine peptide to deliver IL-12 plasmid into stem cells as cancer therapy vehicles. Biotechnol Prog. 2021 Jul;37(4):e3175. doi: 10.1002/btpr.3175. Epub 2021 May 26. PMID: 34013634.

7: Taghavi S, HashemNia A, Mosaffa F, Askarian S, Abnous K, Ramezani M. Preparation and evaluation of polyethylenimine-functionalized carbon nanotubes tagged with 5TR1 aptamer for targeted delivery of Bcl-xL shRNA into breast cancer cells. Colloids Surf B Biointerfaces. 2016 Apr 1;140:28-39. doi: 10.1016/j.colsurfb.2015.12.021. Epub 2015 Dec 17. PMID: 26731195.

8: Ayatollahi S, Hashemi M, Oskuee RK, Salmasi Z, Mokhtarzadeh A, Alibolandi M, Abnous K, Ramezani M. Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells. J Biomater Appl. 2015 Nov;30(5):632-48. doi: 10.1177/0885328215599667. Epub 2015 Aug 11. PMID: 26265706.

9: Oskuee RK, Dehshahri A, Shier WT, Ramezani M. Alkylcarboxylate grafting to polyethylenimine: a simple approach to producing a DNA nanocarrier with low toxicity. J Gene Med. 2009 Oct;11(10):921-32. doi: 10.1002/jgm.1374. PMID: 19634133.

10: Dehshahri A, Oskuee RK, Shier WT, Hatefi A, Ramezani M. Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine. Biomaterials. 2009 Sep;30(25):4187-94. doi: 10.1016/j.biomaterials.2009.04.036. Epub 2009 May 21. PMID: 19464054.

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