BAY-9683

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130264

CAS#: N/A

Description: BAY-9683 BAY-5094 is a covalent PPARG inverse-agonist for use in the treatment of disorders where PPARG is hyperactivated.

Chemical Structure

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BAY-9683
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 130264
Name: BAY-9683
CAS#: N/A
Chemical Formula: C25H22ClF3N4O3
Exact Mass: 518.13
Molecular Weight: 518.920
Elemental Analysis: C, 57.87; H, 4.27; Cl, 6.83; F, 10.98; N, 10.80; O, 9.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BAY-9683; BAY9683; BAY 9683

IUPAC/Chemical Name: 4-chloro-N1-(3,4-difluorobenzyl)-6-fluoro-N3-(3-methyl-5-morpholinopyridin-2-yl)isophthalamide

InChi Key: GBAXCPGBQNNUHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H22ClF3N4O3/c1-14-8-16(33-4-6-36-7-5-33)13-30-23(14)32-25(35)17-10-18(21(28)11-19(17)26)24(34)31-12-15-2-3-20(27)22(29)9-15/h2-3,8-11,13H,4-7,12H2,1H3,(H,31,34)(H,30,32,35)

SMILES Code: O=C(NCC1=CC=C(F)C(F)=C1)C2=C(F)C=C(Cl)C(C(NC3=NC=C(N4CCOCC4)C=C3C)=O)=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 518.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Orsi DL, Ferrara SJ, Siegel S, Friberg A, Bouché L, Pook E, Lienau P, Bluck JP, Lemke CT, Akcay G, Stellfeld T, Meyer H, Pütter V, Holton SJ, Korr D, Jerchel-Furau I, Pantelidou C, Strathdee CA, Meyerson M, Eis K, Goldstein JT. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg Med Chem. 2023 Jan 15;78:117130. doi: 10.1016/j.bmc.2022.117130. Epub 2022 Dec 13. PMID: 36542958.