Bequinostatin C
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MedKoo CAT#: 122919

CAS#: 152175-74-1

Description: Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and GSPT1 inhibitor.

Chemical Structure

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Bequinostatin C
CAS# 152175-74-1
Instruction

Theoretical Analysis

MedKoo Cat#: 122919
Name: Bequinostatin C
CAS#: 152175-74-1
Chemical Formula: C28H22O8
Exact Mass: 486.13
Molecular Weight: 486.480
Elemental Analysis: C, 69.13; H, 4.56; O, 26.31

Price and Availability

Size Price Availability Quantity
1mg USD 850 2 Weeks
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Synonym: Bequinostatin C; DTXSID70164966

IUPAC/Chemical Name: 1,7,9,11-tetrahydroxy-8,13-dioxo-3-pentyl-8,13-dihydrobenzo[a]tetracene-2-carboxylic acid

InChi Key: NJGDHHRUAFIFFQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H22O8/c1-2-3-4-5-12-8-13-6-7-15-16(20(13)26(33)21(12)28(35)36)11-18-23(25(15)32)27(34)22-17(24(18)31)9-14(29)10-19(22)30/h6-11,29-30,32-33H,2-5H2,1H3,(H,35,36)

SMILES Code: O=C(O)C1=C(O)C2=C(C=C34)C(C(O)=C3C(C5=C(O)C=C(O)C=C5C4=O)=O)=CC=C2C=C1CCCCC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 486.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C. Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc. 2007 Aug 1;129(30):9306-12. doi: 10.1021/ja0718624. Epub 2007 Jul 11. PMID: 17625850.


2: Aoyama T, Kojima F, Abe F, Muraoka Y, Naganawa H, Takeuchi T, Aoyagi T. Bequinostatins A and B new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities. J Antibiot (Tokyo). 1993 Jun;46(6):914-20. doi: 10.7164/antibiotics.46.914. PMID: 8344872.


3: Yamazaki T, Tatee T, Aoyama, Kojima F, Takeuchi T, Aoyagi T. Bequinostatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. J Antibiot (Tokyo). 1993 Aug;46(8):1309-11. doi: 10.7164/antibiotics.46.1309. PMID: 8407595.