Broflanilide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130225

CAS#: 1207727-04-5

Description: Broflanilide is an insecticide, targeting pests such as Lepidopteran, Coleopteran, and Thysanopteran.

Chemical Structure

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Broflanilide
CAS# 1207727-04-5
Instruction

Theoretical Analysis

MedKoo Cat#: 130225
Name: Broflanilide
CAS#: 1207727-04-5
Chemical Formula: C25H14BrF11N2O2
Exact Mass: 662.01
Molecular Weight: 663.290
Elemental Analysis: C, 45.27; H, 2.13; Br, 12.05; F, 31.51; N, 4.22; O, 4.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: broflanilide; 1207727-04-5; Broflanilide [ISO]; 5M24RC688M; BROFLANILIDE [JAN]

IUPAC/Chemical Name: N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-3-((2-oxo-2-phenylethyl)amino)benzamide

InChi Key: FEGLSBBQYIRHPU-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H14BrF11N2O2/c26-16-10-13(22(28,24(32,33)34)25(35,36)37)9-15(23(29,30)31)20(16)39-21(41)14-7-4-8-17(19(14)27)38-11-18(40)12-5-2-1-3-6-12/h1-10,38H,11H2,(H,39,41)

SMILES Code: O=C(NC1=C(C(F)(F)F)C=C(C(C(F)(F)F)(F)C(F)(F)F)C=C1Br)C2=CC=CC(NCC(C3=CC=CC=C3)=O)=C2F

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 663.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shen N, Li Y, Leviticus K, Chang XL, Tang T, Cui L, Han ZJ, Zhao CQ. Effect of broflanilide on the phytophagous mite Tetranychus urticae and the predatory mite Typhlodromips swirskii. Pest Manag Sci. 2021 Jun;77(6):2964-2970. doi: 10.1002/ps.6335. Epub 2021 Mar 15. PMID: 33624401.


2: Katsuta H, Nomura M, Wakita T, Daido H, Kobayashi Y, Kawahara A, Banba S. Discovery of broflanilide, a novel insecticide. J Pestic Sci. 2019 May 20;44(2):120-128. doi: 10.1584/jpestics.D18-088. PMID: 31148938; PMCID: PMC6529746.


3: Li R, Cheng S, Chen Z, Guo T, Liang P, Zhen C, Wang J, Zhang L, Liang P, Gao X. Establishment of Toxicity and Susceptibility Baseline of Broflanilide for Aphis gossypii Glove. Insects. 2022 Nov 8;13(11):1033. doi: 10.3390/insects13111033. PMID: 36354856; PMCID: PMC9695941.


4: Wang X, Shi T, Tang P, Liu S, Hou B, Jiang D, Lu J, Yang Y, Carrière Y, Wu Y. Baseline susceptibility of Helicoverpa armigera, Plutella xylostella, and Spodoptera frugiperda to the meta-diamide insecticide broflanilide. Insect Sci. 2022 Nov 3. doi: 10.1111/1744-7917.13142. Epub ahead of print. PMID: 36326623.


5: Sun X, Wei R, Li L, Zhu B, Liang P, Gao X. Resistance and fitness costs in diamondback moths after selection using broflanilide, a novel meta-diamide insecticide. Insect Sci. 2022 Feb;29(1):188-198. doi: 10.1111/1744-7917.12917. Epub 2021 Apr 16. PMID: 33860634.


6: Nakao T, Banba S. Broflanilide: A meta-diamide insecticide with a novel mode of action. Bioorg Med Chem. 2016 Feb 1;24(3):372-7. doi: 10.1016/j.bmc.2015.08.008. Epub 2015 Aug 28. PMID: 26361738.


7: Jia ZQ, Zhan EL, Zhang SG, Jones AK, Zhu L, Wang YN, Huang QT, Han ZJ, Zhao CQ. Sublethal doses of broflanilide prevents molting in the fall armyworm, Spodoptera frugiperda via altering molting hormone biosynthesis. Pestic Biochem Physiol. 2022 Feb;181:105017. doi: 10.1016/j.pestbp.2021.105017. Epub 2021 Dec 23. PMID: 35082040.


8: Wang K, Wang C, Wang J, Dong Y, Che W, Li X. Acute toxicity of broflanilide on neurosecretory system and locomotory behavior of zebrafish (Danio rerio). Chemosphere. 2022 Oct;305:135426. doi: 10.1016/j.chemosphere.2022.135426. Epub 2022 Jun 22. PMID: 35752316.


9: Shen N, Liu HY, Mou TY, Ma YB, Li Y, Song ZJ, Tang T, Han ZJ, Zhao CQ. Novel meta-diamide insecticide, broflanilide, suppresses the population of common cutworm Spodoptera litura through its lethal and sublethal effects. Pest Manag Sci. 2022 Mar;78(3):1081-1089. doi: 10.1002/ps.6719. Epub 2021 Dec 2. PMID: 34786809.


10: Portwood NM, Shayo MF, Tungu PK, Mbewe NJ, Mlay G, Small G, Snetselaar J, Kristan M, Levy P, Walker T, Kirby MJ, Kisinza W, Mosha FW, Rowland M, Messenger LA. Multi-centre discriminating concentration determination of broflanilide and potential for cross-resistance to other public health insecticides in Anopheles vector populations. Sci Rep. 2022 Dec 26;12(1):22359. doi: 10.1038/s41598-022-26990-6. PMID: 36572746; PMCID: PMC9792579.


11: van Herk WG, Vernon RS, Goudis L, Mitchell T. Broflanilide, a Meta-Diamide Insecticide Seed Treatment for Protection of Wheat and Mortality of Wireworms (Agriotes obscurus) in the Field. J Econ Entomol. 2021 Feb 9;114(1):161-173. doi: 10.1093/jee/toaa239. PMID: 33140830.


12: Tang T, Hu F, Wang P, Fu W, Liu X. Broflanilide effectively controls Helicoverpa armigera and Spodoptera exigua exhibiting diverse susceptibilities to chlorantraniliprole and emamectin benzoate. Pest Manag Sci. 2021 Mar;77(3):1262-1272. doi: 10.1002/ps.6139. Epub 2020 Oct 30. PMID: 33063419.


13: Ngufor C, Govoetchan R, Fongnikin A, Vigninou E, Syme T, Akogbeto M, Rowland M. Efficacy of broflanilide (VECTRON T500), a new meta-diamide insecticide, for indoor residual spraying against pyrethroid-resistant malaria vectors. Sci Rep. 2021 Apr 12;11(1):7976. doi: 10.1038/s41598-021-86935-3. PMID: 33846394; PMCID: PMC8042056.


14: Duan M, Zhang J, Liu J, Qian L, Chen X, Zhao F, Zhao W, Zhong Z, Yang Y, Wang C. Toxic effects of broflanilide exposure on development of zebrafish (Danio rerio) embryos and its potential cardiotoxicity mechanism. Environ Pollut. 2021 Oct 1;286:117481. doi: 10.1016/j.envpol.2021.117481. Epub 2021 May 31. PMID: 34126520.


15: Xie G, Zhou W, Jin M, Yu A, Rao L, Jia H, Luo J, He Y, Li B. Residues Analysis and Dissipation Dynamics of Broflanilide in Rice and Its Related Environmental Samples. Int J Anal Chem. 2020 Dec 15;2020:8845387. doi: 10.1155/2020/8845387. PMID: 33381186; PMCID: PMC7755498.


16: Jia ZQ, Zhang YC, Huang QT, Jones AK, Han ZJ, Zhao CQ. Acute toxicity, bioconcentration, elimination, action mode and detoxification metabolism of broflanilide in zebrafish, Danio rerio. J Hazard Mater. 2020 Jul 15;394:122521. doi: 10.1016/j.jhazmat.2020.122521. Epub 2020 Mar 20. PMID: 32279005.


17: Govoetchan R, Fongnikin A, Syme T, Small G, Gbegbo M, Todjinou D, Rowland M, Nimmo D, Padonou GG, Ngufor C. VECTRON™ T500, a new broflanilide insecticide for indoor residual spraying, provides prolonged control of pyrethroid-resistant malaria vectors. Malar J. 2022 Nov 11;21(1):324. doi: 10.1186/s12936-022-04336-x. PMID: 36369006; PMCID: PMC9652911.


18: Chen JC, Cao LJ, Sun LN, Gao YF, Cao HQ, Ma ZZ, Ma LJ, Shen XJ, Wang JX, Gong YJ, Hoffmann AA, Wei SJ. Variation in the toxicity of a novel meta-diamide insecticide, broflanilide, among thrips pest species and developmental stages. Pest Manag Sci. 2022 Dec;78(12):5090-5096. doi: 10.1002/ps.7124. Epub 2022 Sep 14. PMID: 36102347.


19: van Herk WG, Vernon RS, Goudis L, Mitchell T. Protection of Potatoes and Mortality of Wireworms (Agriotes obscurus) With Various Application Methods of Broflanilide, a Novel Meta-Diamide Insecticide. J Econ Entomol. 2022 Dec 14;115(6):1930-1946. doi: 10.1093/jee/toac152. PMID: 36222544.


20: An X, Xu J, Dong F, Liu X, Wu X, Wang R, Zheng Y. Simultaneous determination of broflanilide and its metabolites in five typical Chinese soils by a modified quick, easy, cheap, effective, rugged, and safe method with ultra high performance liquid chromatography and tandem mass spectrometry. J Sep Sci. 2018 Dec;41(24):4515-4524. doi: 10.1002/jssc.201800631. Epub 2018 Nov 14. PMID: 30358086.