JNJ-6204

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MedKoo CAT#: 130128

CAS#: 2765264-50-2

Description: JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM).

Chemical Structure

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JNJ-6204
CAS# 2765264-50-2
Instruction

Theoretical Analysis

MedKoo Cat#: 130128
Name: JNJ-6204
CAS#: 2765264-50-2
Chemical Formula: C19H11D6FN6O
Exact Mass: 370.18
Molecular Weight: 370.420
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 61.61; H, 6.26; F, 5.13; N, 22.69; O, 4.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-6204; JNJ6204; JNJ 6204

IUPAC/Chemical Name: 2-(5-fluoropyridin-2-yl)-6,6-bis(methyl-d3)-3-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine

InChi Key: WZMIWVZGYMKUDV-WFGJKAKNSA-N

InChi Code: InChI=1S/C19H17FN6O/c1-19(2)10-26-15(9-27-19)16(12-5-6-21-18-13(12)8-23-24-18)17(25-26)14-4-3-11(20)7-22-14/h3-8H,9-10H2,1-2H3,(H,21,23,24)/i1D3,2D3

SMILES Code: [2H]C(C(OC1)(C([2H])([2H])[2H])CN2C1=C(C3=C4C(NN=C4)=NC=C3)C(C5=NC=C(F)C=C5)=N2)([2H])[2H]

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Increased CSNK1D expression/activity plays an important role in the pathology of certain cancers, metabolic processes, neurodegenerative diseases, and mood/psychiatric disorders.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. https://patents.google.com/patent/WO2022058920A1/en

2. https://www.eubopen.org/sites/www.eubopen.org/files/chemical-probes/EUbOPEN_ProbeSheet_JNJ-6204_v1.pdf