RTI-122

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MedKoo CAT#: 122725

CAS#: N/A

Description: RTI122 is a GPR88 agonist with IC50=11 nM). RTI-122 was more effective than RTI-13951-33 in attenuating the binge-like alcohol drinking behavior in the drinking-in-the-dark paradigm. RTI-122 is a promising lead compound for drug discovery research of GPR88 agonists

Chemical Structure

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RTI-122
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122725
Name: RTI-122
CAS#: N/A
Chemical Formula: C29H34FN3O3
Exact Mass: 491.26
Molecular Weight: 491.610
Elemental Analysis: C, 70.85; H, 6.97; F, 3.86; N, 8.55; O, 9.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: RTI-122; RTI 122; RTI122

IUPAC/Chemical Name: (1R,2R)-N-((2R,3R)-2-amino-3-methoxybutyl)-2-(5-fluoropyridin-2-yl)-N-(4'-isopropoxy-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxamide

InChi Key: OXODNABCLPQQDT-CEWWTIOHSA-N

InChi Code: InChI=1S/C29H34FN3O3/c1-18(2)36-24-12-7-21(8-13-24)20-5-10-23(11-6-20)33(17-27(31)19(3)35-4)29(34)26-15-25(26)28-14-9-22(30)16-32-28/h5-14,16,18-19,25-27H,15,17,31H2,1-4H3/t19-,25-,26-,27-/m1/s1

SMILES Code: CC(C)OC1=CC=C(C2=CC=C(N(C([C@H]3[C@H](C4=CC=C(F)C=N4)C3)=O)C[C@H]([C@@H](C)OC)N)C=C2)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 491.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R,
Darcq E, Kieffer BL, Jin C. Improvement of the Metabolic Stability of GPR88
Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. J Med Chem.
2023 Feb 7. doi: 10.1021/acs.jmedchem.2c01983. Epub ahead of print. PMID:
36749855.

2: Scheffel U, Dannals RF, Wong DF, Yokoi F, Carroll FI, Kuhar MJ. Dopamine
transporter imaging with novel, selective cocaine analogs. Neuroreport. 1992
Nov;3(11):969-72. doi: 10.1097/00001756-199211000-00005. PMID: 1482766.