5-Carboxystrictosidine

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MedKoo CAT#: 130110

CAS#: 34371-47-6

Description: 5-Carboxystrictosidine, which is found in the medicinal Mappianthus iodoides Hand.-Mazz. root, is a mitochondrial KATP channel activator with evidence suggestive of its potential use to prevent I/R injury of the heart. It was suggested the protective effects may be a result of antioxidant and decreased apoptotic effects achieved through the opening of mitochondrial KATP channels.

Chemical Structure

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5-Carboxystrictosidine
CAS# 34371-47-6
Instruction

Theoretical Analysis

MedKoo Cat#: 130110
Name: 5-Carboxystrictosidine
CAS#: 34371-47-6
Chemical Formula: C28H34N2O11
Exact Mass: 574.22
Molecular Weight: 574.580
Elemental Analysis: C, 58.53; H, 5.96; N, 4.88; O, 30.63

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: 5-Carboxystrictosidine; 5 Carboxystrictosidine; 5Carboxystrictosidine; 5(S)-5-carboxystrictosidine; (5S)-5-carboxystrictosidine

IUPAC/Chemical Name: (1S,3S)-1-(((2S,3R,4S)-5-(methoxycarbonyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-vinyl-3,4-dihydro-2H-pyran-4-yl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

InChi Key: LHKZIVMTXZLOTP-RMKGEEGASA-N

InChi Code: InChI=1S/C28H34N2O11/c1-3-12-14(8-18-21-15(9-19(29-18)25(35)36)13-6-4-5-7-17(13)30-21)16(26(37)38-2)11-39-27(12)41-28-24(34)23(33)22(32)20(10-31)40-28/h3-7,11-12,14,18-20,22-24,27-34H,1,8-10H2,2H3,(H,35,36)/t12-,14+,18+,19+,20-,22-,23+,24-,27+,28+/m1/s1

SMILES Code: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]2OC=C(C(OC)=O)[C@@H](C[C@H]3C4=C(C5=CC=CC=C5N4)C[C@@H](C(O)=O)N3)[C@H]2C=C)[C@@H]1O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 574.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Han Y, Li C, Zhang P, Yang X, Min J, Wu Q, Xie Y, Jin D, Wang Z, Shao F, Quan H. Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels. Eur J Pharmacol. 2022 Apr 5;920:174811. doi: 10.1016/j.ejphar.2022.174811. Epub 2022 Feb 17. PMID: 35182546.