EF-4-177

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122641

CAS#: N/A

Description: EF-4-177 is a CDK2 inhibitor (Kd= 7.4nM) as Male Contraceptives that Reduce Sperm Counts in Mice. EF-4-177 is metabolically stable, orally bioavailable, and significantly disrupts spermatogenesis, demonstrating this series’ therapeutic potential.

Chemical Structure

img
EF-4-177
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122641
Name: EF-4-177
CAS#: N/A
Chemical Formula: C18H14F5N3O2S
Exact Mass: 431.07
Molecular Weight: 431.380
Elemental Analysis: C, 50.12; H, 3.27; F, 22.02; N, 9.74; O, 7.42; S, 7.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: EF-4-177; EF 4-177; EF4-177

IUPAC/Chemical Name: 2-((2-(6-cyano-1H-indol-3-yl)ethyl)amino)-5-(pentafluoro-l6-sulfaneyl)benzoic acid

InChi Key: DODVGTHDEMMYPW-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14F5N3O2S/c19-29(20,21,22,23)13-2-4-16(15(8-13)18(27)28)25-6-5-12-10-26-17-7-11(9-24)1-3-14(12)17/h1-4,7-8,10,25-26H,5-6H2,(H,27,28)

SMILES Code: OC(C1=CC(S(F)(F)(F)(F)F)=CC=C1NCCC2=CNC3=C2C=CC(C#N)=C3)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 431.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Faber EB, Wang N, John K, Sun L, Wong HL, Burban D, Francis R, Tian D, Hong KH, Yang A, Wang L, Elsaid M, Khalid H, Levinson NM, Schönbrunn E, Hawkinson JE, Georg GI. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023 Jan 26. doi: 10.1021/acs.jmedchem.2c01731. Epub ahead of print. PMID: 36701569.