TDI-8414

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MedKoo CAT#: 122508

CAS#: N/A

Description: TDI-8414 is an antimalarial Plasmodium Proteasome Inhibitor. TDI-8414 showed nanomolar antiparasitic activity, no toxicity to HepG2 cells, high selectivity against the Plasmodium proteasome over the human constitutive proteasome and immunoproteasome, improved solubility and PAMPA permeability, and enhanced metabolic stability in microsomes and plasma of both humans and mice.

Chemical Structure

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TDI-8414
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122508
Name: TDI-8414
CAS#: N/A
Chemical Formula: C34H45N5O7S
Exact Mass: 667.30
Molecular Weight: 667.820
Elemental Analysis: C, 61.15; H, 6.79; N, 10.49; O, 16.77; S, 4.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: TDI-8414; TDI8414; TDI 8414

IUPAC/Chemical Name: (5S,8S,11S)-N-cyclopentyl-11-(1,1-dioxidoisothiazolidin-2-yl)-8-(2-morpholinoethyl)-7,10-dioxo-2-oxa-6,9-diaza-1,3(1,3)-dibenzenacyclododecaphane-5-carboxamide

InChi Key: OINUMUZFCZVWJP-CHQNGUEUSA-N

InChi Code: InChI=1S/C34H45N5O7S/c40-32-29(12-14-38-15-17-45-18-16-38)36-34(42)31(39-13-5-19-47(39,43)44)23-25-7-4-11-28(21-25)46-27-10-3-6-24(20-27)22-30(37-32)33(41)35-26-8-1-2-9-26/h3-4,6-7,10-11,20-21,26,29-31H,1-2,5,8-9,12-19,22-23H2,(H,35,41)(H,36,42)(H,37,40)/t29-,30-,31-/m0/s1

SMILES Code: O=C(N[C@@H](CCN1CCOCC1)C(N[C@@H](CC2=CC=CC(O3)=C2)C(NC4CCCC4)=O)=O)[C@H](CC5=CC3=CC=C5)N6CCCS6(=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 667.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Liverton N, Foley M, Meinke PT, Nathan CF, Kirkman LA, Lin G. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. J Med Chem. 2023 Jan 11. doi: 10.1021/acs.jmedchem.2c01651. Epub ahead of print. PMID: 36630286.