2'-Fluoro-2'-Deoxycytidine | CAS# 10212-20-1 | Nucleosides

2'-Fluoro-2'-Deoxycytidine
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122482

CAS#: 10212-20-1

Description: 2'-Fluoro-2'-Deoxycytidine

Chemical Structure

2'-Fluoro-2'-Deoxycytidine

CAS# 10212-20-1

Instruction

Theoretical Analysis

MedKoo Cat#: 122482
Name: 2'-Fluoro-2'-Deoxycytidine
CAS#: 10212-20-1
Chemical Formula: C9H12FN3O4
Exact Mass: 245.08
Molecular Weight: 245.210
Elemental Analysis: C, 44.08; H, 4.93; F, 7.75; N, 17.14; O, 26.10

Price and Availability

Size	Price	Availability
5g	USD 450	2 Weeks
10g	USD 850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 2'-Deoxy-2'-fluorocytidine; 10212-20-1; 2'-Fluoro-2'-deoxycytidine; Cytidine, 2'-deoxy-2'-fluoro-

IUPAC/Chemical Name: 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

InChi Key: NVZFZMCNALTPBY-XVFCMESISA-N

InChi Code: InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1

SMILES Code: O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2F

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 245.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Sala L, Lyshchuk H, Šáchová J, Chvátil D, Kočišek J. Different Mechanisms of
DNA Radiosensitization by 8-Bromoadenosine and 2'-Deoxy-2'-fluorocytidine
Observed on DNA Origami Nanoframe Supports. J Phys Chem Lett. 2022 May
5;13(17):3922-3928. doi: 10.1021/acs.jpclett.2c00584. Epub 2022 Apr 26. PMID:
35472278; PMCID: PMC9083549.

2: Welch SR, Scholte FEM, Flint M, Chatterjee P, Nichol ST, Bergeron É,
Spiropoulou CF. Identification of 2'-deoxy-2'-fluorocytidine as a potent
inhibitor of Crimean-Congo hemorrhagic fever virus replication using a
recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99. doi:
10.1016/j.antiviral.2017.10.008. Epub 2017 Oct 9. PMID: 29024765; PMCID:
PMC8191813.

3: Doerr IL, Fox JJ. Nucleosides. XXXIX. 2'-deoxy-2'-fluorocytidine, 1-beta-D-
arabinofuranosyl-2-amino-1,4(2H)-4-iminopyrimidine, and related derivatives. J
Org Chem. 1967 May;32(5):1462-71. doi: 10.1021/jo01280a035. PMID: 6041430.

4: Stuyver LJ, McBrayer TR, Whitaker T, Tharnish PM, Ramesh M, Lostia S, Cartee
L, Shi J, Hobbs A, Schinazi RF, Watanabe KA, Otto MJ. Inhibition of the
subgenomic hepatitis C virus replicon in huh-7 cells by
2'-deoxy-2'-fluorocytidine. Antimicrob Agents Chemother. 2004 Feb;48(2):651-4.
doi: 10.1128/AAC.48.2.651-654.2004. PMID: 14742230; PMCID: PMC321524.

5: Karim AS, Weltman JK. Transcription of 2'-deoxy-2'-fluoro-modified and
phosphorothioate-modified RNA templates by HIV-1 reverse transcriptase.
Anticancer Res. 1999 Nov-Dec;19(6B):5419-21. PMID: 10697571.

6: Gong Y, Zhang W, Chen L, Lin R, Zhou R, Salter R. Nitro-Activated Nucleobase
Exchange in the Synthesis of 2'-Fluoro-2'-Deoxyribonucleosides. J Org Chem. 2022
Jul 15;87(14):9330-9342. doi: 10.1021/acs.joc.2c01093. Epub 2022 Jun 27. PMID:
35759615.

7: Schmidt S, Niemann A, Krynetskaya NF, Oretskaya TS, Metelev VG, Suchomlinov
VV, Shabarova ZA, Cech D. The use of oligonucleotide probes containing
2'-deoxy-2'-fluoronucleosides for regiospecific cleavage of RNA by RNase H from
Escherichia coli. Biochim Biophys Acta. 1992 Feb 28;1130(1):41-6. doi:
10.1016/0167-4781(92)90459-d. PMID: 1371935.

Your view history

2'-Fluoro-2'-Deoxycytidine featured