(S,R,S)-VL285 Phenol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 121227

CAS#: 1448188-69-9

Description: (S,R,S)-VL285 Phenol is a ProTAC building block. (S,R,S)-VL285 Phenol is used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation, providing an alternative to the widely used VH032. (S,R,S)-VL285 Phenol-linekr conjugates are also available for synthesis of degraders.

Chemical Structure

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(S,R,S)-VL285 Phenol
CAS# 1448188-69-9
Instruction

Theoretical Analysis

MedKoo Cat#: 121227
Name: (S,R,S)-VL285 Phenol
CAS#: 1448188-69-9
Chemical Formula: C29H32N4O5S
Exact Mass: 548.21
Molecular Weight: 548.660
Elemental Analysis: C, 63.49; H, 5.88; N, 10.21; O, 14.58; S, 5.84

Price and Availability

Size Price Availability Quantity
100mg USD 1020 2 Weeks
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Synonym:

IUPAC/Chemical Name: (2S,4R)-4-Hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide

InChi Key: KNZQRBRUYSXXRG-NMVJMZGASA-N

InChi Code: InChI=1S/C29H32N4O5S/c1-16(2)25(33-13-20-6-4-5-7-22(20)28(33)37)29(38)32-14-21(34)11-23(32)27(36)30-12-19-9-8-18(10-24(19)35)26-17(3)31-15-39-26/h4-10,15-16,21,23,25,34-35H,11-14H2,1-3H3,(H,30,36)/t21-,23+,25-/m1/s1

SMILES Code: O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 548.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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