PM 1000

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208541

CAS#: 111635-19-9

Description: PM 1000 (Pueraria mirifica) show notable affects on gonadotrophin and estradiol levels. PM may be effective as an alternative medicine in menopausal women because the effects are not permanent.

Chemical Structure

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PM 1000
CAS# 111635-19-9
Instruction

Theoretical Analysis

MedKoo Cat#: 208541
Name: PM 1000
CAS#: 111635-19-9
Chemical Formula: C18H19NO
Exact Mass: 265.15
Molecular Weight: 265.360
Elemental Analysis: C, 81.47; H, 7.22; N, 5.28; O, 6.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PM 1000, 10-Methyl-11-hydroxyaporphine, 11-Hmapp, 11-Hydroxy-10-methylaporphine

IUPAC/Chemical Name: 4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-6,10-dimethyl-, (R)-

InChi Key: YGOZTDLAUVOPMF-OAHLLOKOSA-N

InChi Code: InChI=1S/C18H19NO/c1-11-6-7-13-10-15-16-12(8-9-19(15)2)4-3-5-14(16)17(13)18(11)20/h3-7,15,20H,8-10H2,1-2H3/t15-/m1/s1

SMILES Code: OC1=C2C3=C4C(CCN(C)[C@]4([H])CC2=CC=C1C)=CC=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 265.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Trisomboon H, Malaivijitnond S, Watanabe G, Cherdshewasart W, Taya K. The estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys. Endocrine. 2006 Feb;29(1):129-34. doi: 10.1385/ENDO:29:1:129. PMID: 16622301.


2: Kariper IA, Üstündağ Z, Caglayan MO. A sensitive spectrophotometric ellipsometry based Aptasensor for the vascular endothelial growth factor detection. Talanta. 2021 Apr 1;225:121982. doi: 10.1016/j.talanta.2020.121982. Epub 2020 Dec 9. PMID: 33592730.


3: Disha, Kumari P, Nayak MK, Kumar P. An electrochemical biosensing platform for progesterone hormone detection using magnetic graphene oxide. J Mater Chem B. 2021 Jul 7;9(26):5264-5271. doi: 10.1039/d1tb00380a. PMID: 34151922.


4: Alex A V, Deosarkar T, N C, Mukherjee A. An ultra-sensitive and selective AChE based colorimetric detection of malathion using silver nanoparticle- graphene oxide (Ag-GO) nanocomposite. Anal Chim Acta. 2021 Jan 15;1142:73-83. doi: 10.1016/j.aca.2020.10.057. Epub 2020 Nov 2. PMID: 33280706.


5: Manonai J, Seif C, Böhler G, Jünemann KP. The effect of Pueraria mirifica on cytologic and urodynamic findings in ovariectomized rats. Menopause. 2009 Mar- Apr;16(2):350-6. doi: 10.1097/gme.0b013e318188b279. PMID: 19098688.


6: Roumeliotis TS, Van Heyst BJ. Size fractionated particulate matter emissions from a broiler house in Southern Ontario, Canada. Sci Total Environ. 2007 Sep 20;383(1-3):174-82. doi: 10.1016/j.scitotenv.2007.05.003. Epub 2007 Jun 19. PMID: 17582466.


7: Trisomboon H, Malaivijitnond S, Watanabe G, Taya K. Ovulation block by Pueraria mirifica: a study of its endocrinological effect in female monkeys. Endocrine. 2005 Feb;26(1):33-9. doi: 10.1385/ENDO:26:1:033. PMID: 15805583.


8: Russell LD, Peterson RN, Russell TA, Hunt W. Electrophoretic map of boar sperm plasma membrane polypeptides and localization and fractionation of specific polypeptide subclasses. Biol Reprod. 1983 Mar;28(2):393-413. doi: 10.1095/biolreprod28.2.393. PMID: 6188498.


9: Sun F, Yin Z, Lun X, Zhao Y, Li R, Shi F, Yu X. Deposition velocity of PM2.5 in the winter and spring above deciduous and coniferous forests in Beijing, China. PLoS One. 2014 May 19;9(5):e97723. doi: 10.1371/journal.pone.0097723. PMID: 24842850; PMCID: PMC4026521.


10: Egli M, Lybrand TP. Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer-Thrombin Complex. J Am Chem Soc. 2019 Mar 13;141(10):4445-4452. doi: 10.1021/jacs.9b00104. Epub 2019 Mar 5. PMID: 30794399.