Plicatin B acrylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208536

CAS#: 72704-01-9

Description: Plicatin B acrylate demonstrates protective effects on micronucleus induction in cultured human lymphocytes by different mutagens

Chemical Structure

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Plicatin B acrylate
CAS# 72704-01-9
Instruction

Theoretical Analysis

MedKoo Cat#: 208536
Name: Plicatin B acrylate
CAS#: 72704-01-9
Chemical Formula: C15H18O3
Exact Mass: 246.13
Molecular Weight: 246.310
Elemental Analysis: C, 73.15; H, 7.37; O, 19.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Plicatin B acrylate,

IUPAC/Chemical Name: 2-Propenoic acid, 3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-, methyl ester, (E)-

InChi Key: LZEOAWXRNGQEHO-RMKNXTFCSA-N

InChi Code: InChI=1S/C15H18O3/c1-11(2)4-7-13-10-12(5-8-14(13)16)6-9-15(17)18-3/h4-6,8-10,16H,7H2,1-3H3/b9-6+

SMILES Code: O=C(OC)/C=C/C1=CC=C(O)C(C/C=C(C)\C)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Eventi A, Lubrano V, Scarpato R, Turchi G. Protective effects of plicatin B on micronucleus induction in cultured human lymphocytes by different mutagens. Food Chem Toxicol. 2009 Jan;47(1):124-8. doi: 10.1016/j.fct.2008.10.017. Epub 2008 Nov 1. PMID: 19007843.


2: Lubrano V, Boni G, L'Abbate A, Turchi G. Antioxidant activity of plicatin B on cultured human microvascular endothelial cells exposed to H2O2. Drug Chem Toxicol. 2007;30(4):311-25. doi: 10.1080/01480540701522148. PMID: 17934921.


3: Nesti C, Trippi F, Scarpato R, Migliore L, Turchi G. Cytokinesis-block micronucleus assay in primary human liver fibroblasts exposed to griseofulvin and mitomycin C. Mutagenesis. 2000 Mar;15(2):143-7. doi: 10.1093/mutage/15.2.143. PMID: 10719040.


4: Maurich T, Pistelli L, Turchi G. Anti-clastogenic activity of two structurally related pterocarpans purified from Bituminaria bituminosa in cultured human lymphocytes. Mutat Res. 2004 Jul 11;561(1-2):75-81. doi: 10.1016/j.mrgentox.2004.03.006. PMID: 15238232.


5: Turchi G, Alagona G, Lubrano V. Protective activity of plicatin B against human LDL oxidation induced in metal ion-dependent and -independent processes. Experimental and theoretical studies. Phytomedicine. 2009 Nov;16(11):1014-26. doi: 10.1016/j.phymed.2009.03.018. Epub 2009 May 8. PMID: 19427772.


6: Maurich T, Iorio M, Chimenti D, Turchi G. Erybraedin C and bitucarpin A, two structurally related pterocarpans purified from Bituminaria bituminosa, induced apoptosis in human colon adenocarcinoma cell lines MMR- and p53-proficient and -deficient in a dose-, time-, and structure-dependent fashion. Chem Biol Interact. 2006 Feb 1;159(2):104-16. doi: 10.1016/j.cbi.2005.10.103. Epub 2005 Nov 3. PMID: 16271357.


7: Scarpato R, Gambacciani C, Svezia B, Chimenti D, Turchi G. Cytotoxicity and genotoxicity studies of two free-radical generators (AAPH and SIN-1) in human microvascular endothelial cells (HMEC-1) and human peripheral lymphocytes. Mutat Res. 2011 May 18;722(1):69-77. doi: 10.1016/j.mrgentox.2011.03.015. Epub 2011 Apr 8. PMID: 21497204.


8: Bertacca A, Cini M, Sbrana M, Turchi G. 3-isobutyl-1-methylxanthine inhibits the mutagenic activity of 7,12-dimethylbenz[a]anthracene in epithelial liver cells in culture. Mutat Res. 1994 Mar;323(3):127-31. doi: 10.1016/0165-7992(94)90086-8. PMID: 7509027.


9: Sbrana I, Puliti A, Seidel A, Glatt H, Turchi G. Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones. Mutagenesis. 1995 Nov;10(6):505-12. doi: 10.1093/mutage/10.6.505. PMID: 8596469.


10: Camici M, Turriani M, Turchi G, Tozzi MG, Cos J, Alemany C, Noe V, Ciudad CJ. Cytotoxicity of deoxycoformycin on human colon carcinoma cell lines. Adv Exp Med Biol. 1994;370:275-8. doi: 10.1007/978-1-4615-2584-4_58. PMID: 7660907.