Lacripep

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208475

CAS#: 2243095-21-6

Description: Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1.

Chemical Structure

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Lacripep
CAS# 2243095-21-6
Instruction

Theoretical Analysis

MedKoo Cat#: 208475
Name: Lacripep
CAS#: 2243095-21-6
Chemical Formula: C106H167N27O29
Exact Mass: 2,282.24
Molecular Weight: 2,283.660
Elemental Analysis: C, 55.75; H, 7.37; N, 16.56; O, 20.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym:

IUPAC/Chemical Name: Ac-Lys-Gln-Phe-Ile-Glu-Asn-Gly-Ser-Glu-Phe-Ala-Gln-Lys-Leu-Leu-Lys-Lys-Phe-Ser-NH2

InChi Key: LQIGMWPYUDATJX-GKKSKUFBSA-N

InChi Code: InChI=1S/C106H167N27O29/c1-9-60(6)88(133-104(160)78(53-65-31-17-12-18-32-65)130-97(153)71(38-42-83(112)138)123-92(148)66(117-62(8)136)33-19-23-45-107)106(162)125-73(40-44-87(143)144)99(155)131-79(54-84(113)139)91(147)115-55-85(140)118-81(57-135)105(161)124-72(39-43-86(141)142)98(154)128-76(51-63-27-13-10-14-28-63)100(156)116-61(7)90(146)119-70(37-41-82(111)137)96(152)121-68(35-21-25-47-109)94(150)126-75(50-59(4)5)102(158)127-74(49-58(2)3)101(157)122-67(34-20-24-46-108)93(149)120-69(36-22-26-48-110)95(151)129-77(52-64-29-15-11-16-30-64)103(159)132-80(56-134)89(114)145/h10-18,27-32,58-61,66-81,88,134-135H,9,19-26,33-57,107-110H2,1-8H3,(H2,111,137)(H2,112,138)(H2,113,139)(H2,114,145)(H,115,147)(H,116,156)(H,117,136)(H,118,140)(H,119,146)(H,120,149)(H,121,152)(H,122,157)(H,123,148)(H,124,161)(H,125,162)(H,126,150)(H,127,158)(H,128,154)(H,129,151)(H,130,153)(H,131,155)(H,132,159)(H,133,160)(H,141,142)(H,143,144)/t60-,61-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,88-/m0/s1

SMILES Code: O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 2,283.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tauber J, Laurie GW, Parsons EC, Odrich MG; Lacripep study group*; Lacripep study group*. Lacripep for the Treatment of Primary Sjögren's-Associated Ocular Surface Disease: Results of the First-In-Human Study. Cornea. 2022 Aug 3. doi: 10.1097/ICO.0000000000003091. Epub ahead of print. PMID: 35942530.


2: Lee C, Edman MC, Laurie GW, Hamm-Alvarez SF, MacKay JA. Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium. Int J Mol Sci. 2020 Aug 26;21(17):6157. doi: 10.3390/ijms21176157. PMID: 32859014; PMCID: PMC7504496.


3: Efraim Y, Chen FYT, Cheong KN, Gaylord EA, McNamara NA, Knox SM. A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration. Cell Rep. 2022 Aug 30;40(9):111307. doi: 10.1016/j.celrep.2022.111307. PMID: 36044852.