GB1874

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208444

CAS#: 1011440-46-2

Description: GB1874 inhibitor of the Wnt pathway that targets the β-cat-TCF4 PPI. GB1874 also affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro. Encouragingly, GB1874 inhibited the growth of CRC tumor xenografts in vivo, thus demonstrating its potential for further development into therapeutics against Wnt-associated cancer indications.

Chemical Structure

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GB1874
CAS# 1011440-46-2
Instruction

Theoretical Analysis

MedKoo Cat#: 208444
Name: GB1874
CAS#: 1011440-46-2
Chemical Formula: C24H27N3O2S
Exact Mass: 421.18
Molecular Weight: 421.560
Elemental Analysis: C, 68.38; H, 6.46; N, 9.97; O, 7.59; S, 7.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GB-1874, GB-18-74

IUPAC/Chemical Name: 2-((5-((4-Ethylphenoxy)methyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl)thio)cyclopentan-1-one

InChi Key: YXVSHQBEMJQNCX-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27N3O2S/c1-3-18-12-14-20(15-13-18)29-16-23-25-26-24(30-22-11-7-10-21(22)28)27(23)17(2)19-8-5-4-6-9-19/h4-6,8-9,12-15,17,22H,3,7,10-11,16H2,1-2H3

SMILES Code: O=C1C(SC2=NN=C(COC3=CC=C(CC)C=C3)N2C(C4=CC=CC=C4)C)CCC1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 421.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Low JL, Du W, Gocha T, Oguz G, Zhang X, Chen MW, Masirevic S, Yim DGR, Tan IBH, Ramasamy A, Fan H, DasGupta R. Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction. iScience. 2021 May 15;24(6):102544. doi: 10.1016/j.isci.2021.102544. PMID: 34142050; PMCID: PMC8184503.