RdRp inhibitor 11q

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208319

CAS#: unknown

Description: RdRp inhibitor 11q is one of a series of novel aryl benzoyl hydrazide analogs as potent anti-influenza agents. It exhibited potent inhibitory activity against the avian H5N1 flu strain with EC50 values ranging from 0.009 to 0.034 μM. Moreover, compound 11q exhibited nanomolar antiviral effects against both the H1N1 virus and Flu B virus and possessed good oral bioavailability and inhibitory activity against influenza A virus in a mouse model.

Chemical Structure

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RdRp inhibitor 11q
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 208319
Name: RdRp inhibitor 11q
CAS#: unknown
Chemical Formula: C17H17Br2N3O2
Exact Mass: 452.97
Molecular Weight: 455.150
Elemental Analysis: C, 44.86; H, 3.76; Br, 35.11; N, 9.23; O, 7.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Rdrp inhibitor 11q, RdRp-inhibitor 11q, RdRp-inhibitor-11q

IUPAC/Chemical Name: N'-(2,6-Dibromophenyl)-4-morpholinobenzohydrazide

InChi Key: YQWKGPHJXLAMOI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17Br2N3O2/c18-14-2-1-3-15(19)16(14)20-21-17(23)12-4-6-13(7-5-12)22-8-10-24-11-9-22/h1-7,20H,8-11H2,(H,21,23)

SMILES Code: O=C(NNC1=C(Br)C=CC=C1Br)C2=CC=C(N3CCOCC3)C=C2

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 455.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Liu X, Liang J, Yu Y, Han X, Yu L, Chen F, Xu Z, Chen Q, Jin M, Dong C, Zhou HB, Lan K, Wu S. Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp). J Med Chem. 2022 Mar 10;65(5):3814-3832. doi: 10.1021/acs.jmedchem.1c01257. Epub 2022 Feb 25. PMID: 35212527.