5-FU Prodrug 4

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208163

CAS#: unknown

Description: 5-FU Prodrug 4 is a palladium-activated 5-FU prodrug. Over the past four decades, several modulation strategies including the implementation of 5-FU-based combination regimens and 5-FU pro-drugs have been developed and tested to increase the anti-tumor activity of 5-FU and to overcome the clinical resistance.

Chemical Structure

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5-FU Prodrug 4
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 208163
Name: 5-FU Prodrug 4
CAS#: unknown
Chemical Formula: C10H7FN2O2
Exact Mass: 206.05
Molecular Weight: 206.180
Elemental Analysis: Chemical Formula: C10H7FN2O2 Exact Mass: 206.0492 Molecular Weight: 206.1764 Elemental Analysis: C, 58.26; H, 3.42; F, 9.21; N, 13.59; O, 15.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 5FU Prodrug 4, 5FUProdrug 4

IUPAC/Chemical Name: 5-Fluoro-2,4-bis(prop-2-yn-1-yloxy)pyrimidine

InChi Key: UEJQGOKMPMUMTO-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H7FN2O2/c1-3-5-14-9-8(11)7-12-10(13-9)15-6-4-2/h1-2,7H,5-6H2

SMILES Code: C#CCOC1=NC=C(F)C(OCC#C)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 206.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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10: Sasaki E, Tominaga K, Kuwamura H, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T. Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism. J Gastroenterol. 2007 Oct;42(10):816-22. doi: 10.1007/s00535-007-2101-5. Epub 2007 Oct 15. PMID: 17940834.