Sandramycin
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MedKoo CAT#: 112151

CAS#: 100940-65-6

Description: Sandramycin is a cyclic depsipeptide antibiotic that is active against Gram-positive bacteria in vitro and leukemia P388 tumors in mice.

Chemical Structure

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Sandramycin
CAS# 100940-65-6
Instruction

Theoretical Analysis

MedKoo Cat#: 112151
Name: Sandramycin
CAS#: 100940-65-6
Chemical Formula: C60H76N12O16
Exact Mass: 1,220.55
Molecular Weight: 1,221.340
Elemental Analysis: C, 59.01; H, 6.27; N, 13.76; O, 20.96

Price and Availability

Size Price Availability Quantity
1mg USD 530 2 Weeks
5mg USD 1480 2 Weeks
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Synonym: Sandramycin; (-)-Sandramycin

IUPAC/Chemical Name: N,N'-((7R,11S,19aS,26R,30S,38aS)-11,30-diisopropyl-12,15,31,34-tetramethyl-6,10,13,16,19,25,29,32,35,38-decaoxodotriacontahydro-2H,6H,10H,25H-dipyrido[2,1-b1:2',1'-l][1,17]dioxa[4,7,10,13,20,23,26,29]octaazacyclodotriacontine-7,26-diyl)bis(3-hydroxyquinoline-2-carboxamide)

InChi Key: WXIVYIYCEBUEHL-RTQGILJWSA-N

InChi Code: InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)/t39-,40-,41+,42+,51+,52+/m1/s1

SMILES Code: O=C(N1CCCC[C@]1(C(NCC(N(C)CC(N(C)[C@@H](C(C)C)C(OC[C@H]2NC(C3=NC4=C(C=C3O)C=CC=C4)=O)=O)=O)=O)=O)[H])[C@H](NC(C5=NC6=C(C=C5O)C=CC=C6)=O)COC([C@H](C(C)C)N(C)C(CN(C)C(CNC([C@]7([H])CCCCN7C2=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,221.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Matson JA, Bush JA. Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties. J Antibiot (Tokyo). 1989 Dec;42(12):1763-7. doi: 10.7164/antibiotics.42.1763. PMID: 2621159.


2: Matson JA, Colson KL, Belofsky GN, Bleiberg BB. Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. II. Structure determination. J Antibiot (Tokyo). 1993 Jan;46(1):162-6. doi: 10.7164/antibiotics.46.162. PMID: 8436549.


3: Boger DL, Saionz KW. DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. Bioorg Med Chem. 1999 Feb;7(2):315-21. doi: 10.1016/s0968-0896(98)00206-5. PMID: 10218823.


4: Hu J, Zhang C, Na R, Li Y. [A actinomycete strain C3905 producing antitumor antibiotic sandramycin from Antarctica]. Wei Sheng Wu Xue Bao. 2000 Dec;40(6):646-51. Chinese. PMID: 12549061.