(S,R,S)-AHPC-C8-NH2
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MedKoo CAT#: 577885

CAS#: 2341796-79-8

Description: (S,R,S)-AHPC-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader.

Chemical Structure

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(S,R,S)-AHPC-C8-NH2
CAS# 2341796-79-8
Instruction

Theoretical Analysis

MedKoo Cat#: 577885
Name: (S,R,S)-AHPC-C8-NH2
CAS#: 2341796-79-8
Chemical Formula: C31H47N5O4S
Exact Mass: 585.33
Molecular Weight: 585.810
Elemental Analysis: C, 63.56; H, 8.09; N, 11.96; O, 10.92; S, 5.47

Price and Availability

Size Price Availability Quantity
50mg USD 735 2 Weeks
100mg USD 1100 2 Weeks
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Synonym: (S,R,S)-AHPC-C8-NH2; VH032-C8-NH2

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-(9-aminononanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key: QLJZVMJBYNFUSG-CERRFVOPSA-N

InChi Code: InChI=1S/C31H47N5O4S/c1-21-27(41-20-34-21)23-14-12-22(13-15-23)18-33-29(39)25-17-24(37)19-36(25)30(40)28(31(2,3)4)35-26(38)11-9-7-5-6-8-10-16-32/h12-15,20,24-25,28,37H,5-11,16-19,32H2,1-4H3,(H,33,39)(H,35,38)/t24-,25+,28-/m1/s1

SMILES Code: O=C([C@H]1N(C([C@@H](NC(CCCCCCCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 585.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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