CGP-49823

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466090

CAS#: 150705-88-7

Description: CGP-49823 is a non-peptide tachykinin NK1 receptor antagonist.

Chemical Structure

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CGP-49823
CAS# 150705-88-7
Instruction

Theoretical Analysis

MedKoo Cat#: 466090
Name: CGP-49823
CAS#: 150705-88-7
Chemical Formula: C31H33N3O
Exact Mass: 463.26
Molecular Weight: 463.625
Elemental Analysis: C, 80.31; H, 7.17; N, 9.06; O, 3.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CGP-49823; CGP49823; CGP 49823;

IUPAC/Chemical Name: {(R)-2-Benzyl-4-[(quinolin-4-ylmethyl)-amino]-piperidin-1-yl}-(3,5-dimethyl-phenyl)-methanone

InChi Key: WQZUOBIIPDZRJP-QXPUDEPPSA-N

InChi Code: InChI=1S/C31H33N3O/c1-22-16-23(2)18-26(17-22)31(35)34-15-13-27(20-28(34)19-24-8-4-3-5-9-24)33-21-25-12-14-32-30-11-7-6-10-29(25)30/h3-12,14,16-18,27-28,33H,13,15,19-21H2,1-2H3/t27-,28?/m1/s1

SMILES Code: CC1=CC(C(N2C(CC3=CC=CC=C3)C[C@H](NCC4=CC=NC5=CC=CC=C45)CC2)=O)=CC(C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 463.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Khawaja AM, Liu Y, Rogers DF. Effect of non-peptide tachykinin NK(1) receptor antagonists on non-adrenergic, non-cholinergic neurogenic mucus secretion in ferret trachea. Eur J Pharmacol. 1999 Nov 19;384(2-3):173-81. doi: 10.1016/s0014-2999(99)00694-9. PMID: 10611439.

2: Pozza MF, Olpe HR, Ofner S, Schoeffel C, Evans RH. The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342(2-3):203-8. doi: 10.1016/s0014-2999(97)01500-8. PMID: 9548386.

3: File SE. Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 1997 Nov;58(3):747-52. doi: 10.1016/s0091-3057(97)90002-2. PMID: 9329068.