JNJ-A07
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MedKoo CAT#: 466030

CAS#: 2135640-93-4

Description: JNJ-A07 is a novel pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.

Chemical Structure

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JNJ-A07
CAS# 2135640-93-4
Instruction

Theoretical Analysis

MedKoo Cat#: 466030
Name: JNJ-A07
CAS#: 2135640-93-4
Chemical Formula: C28H26ClF3N2O6
Exact Mass: 578.14
Molecular Weight: 578.969
Elemental Analysis: C, 58.09; H, 4.53; Cl, 6.12; F, 9.84; N, 4.84; O, 16.58

Price and Availability

Size Price Availability Quantity
5mg USD 750 2 Weeks
10mg USD 1250 2 Weeks
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Synonym: JNJ-A07; JNJA07; JNJ A07;

IUPAC/Chemical Name: (S)-4-(3-((1-(4-chlorophenyl)-2-oxo-2-(6-(trifluoromethoxy)indolin-1-yl)ethyl)amino)-5-methoxyphenoxy)butanoic acid

InChi Key: WUBVXTOLZKVNEG-SANMLTNESA-N

InChi Code: InChI=1S/C28H26ClF3N2O6/c1-38-22-13-20(14-23(15-22)39-12-2-3-25(35)36)33-26(18-4-7-19(29)8-5-18)27(37)34-11-10-17-6-9-21(16-24(17)34)40-28(30,31)32/h4-9,13-16,26,33H,2-3,10-12H2,1H3,(H,35,36)/t26-/m0/s1

SMILES Code: COC1=CC(OCCCC(O)=O)=CC(N[C@@H](C2=CC=C(Cl)C=C2)C(N3C(C=C(OC(F)(F)F)C=C4)=C4CC3)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 578.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kaptein SJF, Goethals O, Kiemel D, Marchand A, Kesteleyn B, Bonfanti JF, Bardiot D, Stoops B, Jonckers THM, Dallmeier K, Geluykens P, Thys K, Crabbe M, Chatel-Chaix L, Münster M, Querat G, Touret F, de Lamballerie X, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Van Loock M, Neyts J. A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. Nature. 2021 Oct;598(7881):504-509. doi: 10.1038/s41586-021-03990-6. Epub 2021 Oct 6. Erratum in: Nature. 2021 Nov;599(7883):E2. PMID: 34616043.