WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465678

CAS#: unknown

Description: T-278 is a novel potent inhibitor of DGKγ (IC50 = 30 nM) with desirable physicochemical properties allowing efficient blood-brain barrier penetration and low levels of undesirable nonspecific binding.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465678
Name: T-278
CAS#: unknown
Chemical Formula: C20H21N3O4
Exact Mass: 367.1532
Molecular Weight: 367.405
Elemental Analysis: C, 65.38; H, 5.76; N, 11.44; O, 17.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: T-278; T278; T 278;

IUPAC/Chemical Name: 2-((3-acetyl-1-(6-methoxypyridin-3-yl)-2-methyl-1H-indol-5-yl)oxy)-N-methylacetamide


InChi Code: InChI=1S/C20H21N3O4/c1-12-20(13(2)24)16-9-15(27-11-18(25)21-3)6-7-17(16)23(12)14-5-8-19(26-4)22-10-14/h5-10H,11H2,1-4H3,(H,21,25)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 367.405 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hattori Y, Yamasaki T, Ohashi T, Miyanohana Y, Kusumoto T, Maeda R, Miyamoto M, Debori Y, Hata A, Zhang Y, Wakizaka H, Wakabayashi T, Fujinaga M, Yamashita R, Zhang MR, Koike T. Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain. J Med Chem. 2021 Aug 26;64(16):11990-12002. doi: 10.1021/acs.jmedchem.1c00584. Epub 2021 Aug 4. PMID: 34347478.