WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465678
CAS#: unknown
Description: T-278 is a novel potent inhibitor of DGKγ (IC50 = 30 nM) with desirable physicochemical properties allowing efficient blood-brain barrier penetration and low levels of undesirable nonspecific binding.
MedKoo Cat#: 465678
Name: T-278
CAS#: unknown
Chemical Formula: C20H21N3O4
Exact Mass: 367.1532
Molecular Weight: 367.405
Elemental Analysis: C, 65.38; H, 5.76; N, 11.44; O, 17.42
This product is not in stock, which may be available by custom synthesis.
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Synonym: T-278; T278; T 278;
IUPAC/Chemical Name: 2-((3-acetyl-1-(6-methoxypyridin-3-yl)-2-methyl-1H-indol-5-yl)oxy)-N-methylacetamide
InChi Key: KQQUNUYGULEUGW-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H21N3O4/c1-12-20(13(2)24)16-9-15(27-11-18(25)21-3)6-7-17(16)23(12)14-5-8-19(26-4)22-10-14/h5-10H,11H2,1-4H3,(H,21,25)
SMILES Code: O=C(NC)COC1=CC2=C(N(C3=CC=C(OC)N=C3)C(C)=C2C(C)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 367.405 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hattori Y, Yamasaki T, Ohashi T, Miyanohana Y, Kusumoto T, Maeda R, Miyamoto M, Debori Y, Hata A, Zhang Y, Wakizaka H, Wakabayashi T, Fujinaga M, Yamashita R, Zhang MR, Koike T. Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain. J Med Chem. 2021 Aug 26;64(16):11990-12002. doi: 10.1021/acs.jmedchem.1c00584. Epub 2021 Aug 4. PMID: 34347478.
