RUN-00530
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465565

CAS#: unknown

Description: RUN-00530 is a functionalized cereblon ligand for PROTAC® research and development. It incorporates an E3 ligase ligand with a terminal piperidine for onward chemistry to generate Protein Degraders with rigid linkers. It is part of a range of functionalized tool molecules for PROTAC® Degrader R&D. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

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RUN-00530
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465565
Name: RUN-00530
CAS#: unknown
Chemical Formula: C23H30Cl2FN5O4
Exact Mass: 529.17
Molecular Weight: 530.422
Elemental Analysis: C, 52.08; H, 5.70; Cl, 13.37; F, 3.58; N, 13.20; O, 12.07

Price and Availability

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25mg USD 550 2 Weeks
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Synonym: RUN-00530; RUN00530; RUN 00530; Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine;

IUPAC/Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-(piperidin-4-ylmethyl)piperazin-1-yl)isoindoline-1,3-dione dihydrochloride

InChi Key: RPBQFDUBJGNGHE-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H28FN5O4.2ClH/c24-17-11-15-16(23(33)29(22(15)32)18-1-2-20(30)26-21(18)31)12-19(17)28-9-7-27(8-10-28)13-14-3-5-25-6-4-14;;/h11-12,14,18,25H,1-10,13H2,(H,26,30,31);2*1H

SMILES Code: FC1=C(C=C2C(N(C3CCC(NC3=O)=O)C(C2=C1)=O)=O)N4CCN(CC5CCNCC5)CC4.Cl.Cl

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 530.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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