Neostigmine hydroxide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577432

CAS#: 588-17-0

Description: Neostigmine hydroxide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Chemical Structure

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Neostigmine hydroxide
CAS# 588-17-0
Instruction

Theoretical Analysis

MedKoo Cat#: 577432
Name: Neostigmine hydroxide
CAS#: 588-17-0
Chemical Formula: C12H20N2O3
Exact Mass: 240.15
Molecular Weight: 240.300
Elemental Analysis: C, 59.98; H, 8.39; N, 11.66; O, 19.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Neostigmine hydroxide

IUPAC/Chemical Name: Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-, hydroxide (1:1)

InChi Key: GTPJMRHVDZUPND-UHFFFAOYSA-M

InChi Code: InChI=1S/C12H19N2O2.H2O/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H2/q+1;/p-1

SMILES Code: [OH-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 240.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Yang L, Yang D, Li Q, Zuo Y, Lu D. Neostigmine for reversal of neuromuscular block in paediatric patients. Cochrane Database Syst Rev. 2014 May 5;(5):CD010110. doi: 10.1002/14651858.CD010110.pub2. PMID: 24793636.