NJH-2-057
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MedKoo CAT#: 465515

CAS#: unknown

Description: NJH-2-057 is a novel covalent allosteric OTUB1-recruiting DUBTAG, robustly stabilizing DF508-CFTR in human cystic fibrosis bronchial epithelial cells in an OTUB1-dependent manner.

Chemical Structure

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NJH-2-057
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465515
Name: NJH-2-057
CAS#: unknown
Chemical Formula: C43H44F2N6O8
Exact Mass: 810.32
Molecular Weight: 810.856
Elemental Analysis: C, 63.69; H, 5.47; F, 4.69; N, 10.36; O, 15.78

Price and Availability

Size Price Availability Quantity
5mg USD 550 2 Weeks
10mg USD 950 2 Weeks
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Synonym: NJH-2-057; NJH2-057; NJH 2-057; NJH-2057; NJH-2 057; NJH2057 NJH 2 057;

IUPAC/Chemical Name: N-(5-(3-(5-(4-acryloyl-2-oxopiperazin-1-yl)furan-2-yl)propanamido)pentyl)-3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzamide

InChi Key: GBRJFUUBXKOHMN-UHFFFAOYSA-N

InChi Code: InChI=1S/C43H44F2N6O8/c1-3-36(53)50-22-23-51(37(54)26-50)38-17-13-31(57-38)12-16-35(52)46-20-5-4-6-21-47-40(55)29-9-7-8-28(24-29)39-27(2)10-15-34(48-39)49-41(56)42(18-19-42)30-11-14-32-33(25-30)59-43(44,45)58-32/h3,7-11,13-15,17,24-25H,1,4-6,12,16,18-23,26H2,2H3,(H,46,52)(H,47,55)(H,48,49,56)

SMILES Code: O=C(NCCCCCNC(CCC1=CC=C(N2C(CN(C(C=C)=O)CC2)=O)O1)=O)C3=CC=CC(C4=NC(NC(C5(C6=CC=C(OC(F)(F)O7)C7=C6)CC5)=O)=CC=C4C)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 810.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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