Pelanserin Free Base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414830

CAS#: 2208-51-7 (free base)

Description: Pelanserin Free Base is an antagonist of the 5-HT2 and α1-adrenergic receptors.

Chemical Structure

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Pelanserin Free Base
CAS# 2208-51-7 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 414830
Name: Pelanserin Free Base
CAS#: 2208-51-7 (free base)
Chemical Formula: C21H24N4O2
Exact Mass: 364.19
Molecular Weight: 364.450
Elemental Analysis: C, 69.21; H, 6.64; N, 15.37; O, 8.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 42877-18-9 (HCl); 2208-51-7 (free base)  

Synonym: Pelanserin Free Base; Pelanserine; Pelanserinum

IUPAC/Chemical Name: 2,4(1H,3H)-Quinazolinedione, 3-(3-(4-phenyl-1-piperazinyl)propyl)-

InChi Key: WPKPLSFHHBBLRY-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H24N4O2/c26-20-18-9-4-5-10-19(18)22-21(27)25(20)12-6-11-23-13-15-24(16-14-23)17-7-2-1-3-8-17/h1-5,7-10H,6,11-16H2,(H,22,27)

SMILES Code: O=C(N1CCCN2CCN(C3=CC=CC=C3)CC2)NC4=C(C=CC=C4)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 364.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Aguirre Hernández G, Somanathan R, Bernès S. Pelanserin: 3-[3-(4-phenyl- piperazin-1-yl)prop-yl]quinazoline-2,4(1H,3H)-dione. Acta Crystallogr Sect E Struct Rep Online. 2014 Jul 23;70(Pt 8):o878. doi: 10.1107/S160053681401602X. PMID: 25249922; PMCID: PMC4158516.

2: Espinoza R, Hong E, Villafuerte L. Influence of admixed citric acid on the release profile of pelanserin hydrochloride from HPMC matrix tablets. Int J Pharm. 2000 May 25;201(2):165-73. doi: 10.1016/s0378-5173(00)00406-3. PMID: 10878323.

3: Flores Murrieta FJ, Castañeda Hernández G, Hong E. Farmacocinetica y efecto antihipertensivo de la pelanserina en perros [Pharmacokinetics and antihypertensive effect of pelanserin in dogs ]. Arch Inst Cardiol Mex. 1990 Jul-Aug;60(4):347-51. Spanish. PMID: 2268171.

4: Villalobos-Molina R, Ibarra M, Hong E. The 5-HT2 receptor antagonist, pelanserin, inhibits alpha 1-adrenoceptor-mediated vasoconstriction in vitro. Eur J Pharmacol. 1995 Apr 24;277(2-3):181-5. doi: 10.1016/0014-2999(95)00074-u. PMID: 7493607.

5: Flores-Murrieta FJ, Castañeda-Hernández G, Hong E. Pharmacokinetics and antihypertensive effect of oral pelanserin in renal hypertensive dogs. Arzneimittelforschung. 1992 Sep;42(9):1105-8. PMID: 1445477.

6: Flores-Murrieta FJ, Herrera JE, Castañeda-Hernández G, Hong E. Pharmacokinetics of pelanserin in healthy volunteers. Proc West Pharmacol Soc. 1992;35:113-6. PMID: 1502209.

7: Hong E, Castillo C, Flores E, Mercedes F. Receptores serotoninérgicos y enfermedades cardiovasculares [Serotoninergic receptors and cardiovascular diseases]. Gac Med Mex. 1994 May-Jun;130(3):131-3. Spanish. PMID: 7657075.

8: Flores-Murrieta FJ, Hong E, Castañeda-Hernández G. Sensitive high-performance liquid chromatographic assay of pelanserin, a novel antihypertensive agent, in plasma samples. J Chromatogr. 1988 Jun 24;428(1):167-72. doi: 10.1016/s0378-4347(00)83903-1. PMID: 3170670.

9: Flores-Murrieta FJ, Castañeda-Hernández G, Hong E. Determination of pelanserin in human plasma by high-performance liquid chromatography with amperometric detection. J Chromatogr. 1990 Jun 29;528(2):501-8. doi: 10.1016/s0378-4347(00)82410-x. PMID: 2384588.

10: Campos-Lara G, Caracheo F, Valencia-Sánchez A, Ponce-Monter H. The sensitivity of rat uterus to serotonin in vitro is a late estrogenic response. Arch Invest Med (Mex). 1990 Jan-Mar;21(1):71-5. PMID: 2222119.