RMG8-8

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465416

CAS#: unknown

Description: RMG8-8 is an antifungal peptoid. Though the efficacy of RMG8-8 against C. albicans was modest (25 μg/mL), the efficacy against C. neoformans was excellent (1.56 μg/mL). Cytotoxicity against a panel of cell lines proved RMG8-8 to be minimally toxic, with selectivity ratios ranging from 34 to 121. Additional studies were carried out to determine the pharmacological importance of each peptoid monomer in RMG8-8, characterize the killing kinetics of this compound against C. neoformans (t1/2 = 6.5 min), and evaluate plasma protein binding and proteolytic stability. Finally, a liposomal lysis assay suggested that RMG8-8 likely exerts fungal killing through membrane permeabilization, the generally accepted mechanism of action for most antimicrobial peptides and peptoids.

Chemical Structure

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RMG8-8
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 465416
Name: RMG8-8
CAS#: unknown
Chemical Formula: C41H80N8O5
Exact Mass: 764.63
Molecular Weight: 765.142
Elemental Analysis: C, 64.36; H, 10.54; N, 14.65; O, 10.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: RMG8-8; RMG88; RMG8 8;

IUPAC/Chemical Name: N-(4-(l4-azanyl)butyl)-N-(2-((2-(l4-azanyl)ethyl)(2-((2-amino-2-oxoethyl)(cyclohexyl)amino)-2-oxoethyl)amino)-2-oxoethyl)-2-(N-cyclohexyl-2-(tridecylamino)acetamido)acetamide

InChi Key: JTGSBQPGDKEAMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C41H80N8O5/c1-2-3-4-5-6-7-8-9-10-11-19-27-45-30-38(51)49(36-23-16-13-17-24-36)34-40(53)46(28-20-18-25-42)32-39(52)47(29-26-43)33-41(54)48(31-37(44)50)35-21-14-12-15-22-35/h35-36,45H,2-34H2,1,42-43H3,(H2,44,50)

SMILES Code: O=C(N(C1CCCCC1)CC(N(CCCC[NH3])CC(N(CC[NH3])CC(N(C2CCCCC2)CC(N)=O)=O)=O)=O)CNCCCCCCCCCCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 765.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang S, Asuke S, Vy TTP, Inoue Y, Chuma I, Win J, Kato K, Tosa Y. A New Resistance Gene in Combination with Rmg8 Confers Strong Resistance Against Triticum Isolates of Pyricularia oryzae in a Common Wheat Landrace. Phytopathology. 2018 Nov;108(11):1299-1306. doi: 10.1094/PHYTO-12-17-0400-R. Epub 2018 Sep 11. PMID: 29767554.