WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206187
Description: NRX-204647 is a RARγ-selective inverse agonist.
MedKoo Cat#: 206187
Chemical Formula: C24H27NO3
Exact Mass: 377.19909
Molecular Weight: 377.48
Elemental Analysis: C, 76.36; H, 7.21; N, 3.71; O, 12.72
NRX-20464 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: NRX204647; NRX-204647; NRX 204647.
IUPAC/Chemical Name: 4-((1E,3Z)-3-(hydroxyimino)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid
InChi Key: DKMAOOMRQCCGEO-LOOVLXKESA-N
InChi Code: InChI=1S/C24H27NO3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25-28)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,28H,13-14H2,1-4H3,(H,26,27)/b12-7+,25-21-
SMILES Code: O=C(O)C1=CC=C(/C=C/C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=N/O)C=C1
The following data is based on the product molecular weight 377.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Janesick A, Nguyen TT, Aisaki K, Igarashi K, Kitajima S, Chandraratna RA, Kanno J, Blumberg B. Active repression by RARγ signaling is required for vertebrate axial elongation. Development. 2014 Jun;141(11):2260-70. doi: 10.1242/dev.103705. Epub 2014 May 12. PubMed PMID: 24821986.