NRX-204647

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206187

CAS#: 1351452-80-6

Description: NRX-204647 is a RARγ-selective inverse agonist.


Chemical Structure

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NRX-204647
CAS# 1351452-80-6

Theoretical Analysis

MedKoo Cat#: 206187
Name: NRX-204647
CAS#: 1351452-80-6
Chemical Formula: C24H27NO3
Exact Mass: 377.19909
Molecular Weight: 377.48
Elemental Analysis: C, 76.36; H, 7.21; N, 3.71; O, 12.72

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Synonym: NRX204647; NRX-204647; NRX 204647.

IUPAC/Chemical Name: 4-((1E,3Z)-3-(hydroxyimino)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid

InChi Key: DKMAOOMRQCCGEO-LOOVLXKESA-N

InChi Code: InChI=1S/C24H27NO3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25-28)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,28H,13-14H2,1-4H3,(H,26,27)/b12-7+,25-21-

SMILES Code: O=C(O)C1=CC=C(/C=C/C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=N/O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 377.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Janesick A, Nguyen TT, Aisaki K, Igarashi K, Kitajima S, Chandraratna RA, Kanno J, Blumberg B. Active repression by RARγ signaling is required for vertebrate axial elongation. Development. 2014 Jun;141(11):2260-70. doi: 10.1242/dev.103705. Epub 2014 May 12. PubMed PMID: 24821986.  



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