NRX-204647

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206187

CAS#: 1351452-80-6

Description: NRX-204647 is a RARγ-selective inverse agonist.

Chemical Structure

NRX-204647

CAS# 1351452-80-6

Instruction

Theoretical Analysis

MedKoo Cat#: 206187
Name: NRX-204647
CAS#: 1351452-80-6
Chemical Formula: C24H27NO3
Exact Mass: 377.20
Molecular Weight: 377.480
Elemental Analysis: C, 76.36; H, 7.21; N, 3.71; O, 12.72

Price and Availability

Size	Price	Availability	Quantity
1g	USD -1
2g	USD -1
5g	USD -1
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NRX204647; NRX-204647; NRX 204647.

IUPAC/Chemical Name: 4-((1E,3Z)-3-(hydroxyimino)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid

InChi Key: DKMAOOMRQCCGEO-LOOVLXKESA-N

InChi Code: InChI=1S/C24H27NO3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25-28)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,28H,13-14H2,1-4H3,(H,26,27)/b12-7+,25-21-

SMILES Code: O=C(O)C1=CC=C(/C=C/C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=N/O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 377.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Janesick A, Nguyen TT, Aisaki K, Igarashi K, Kitajima S, Chandraratna RA, Kanno J, Blumberg B. Active repression by RARγ signaling is required for vertebrate axial elongation. Development. 2014 Jun;141(11):2260-70. doi: 10.1242/dev.103705. Epub 2014 May 12. PubMed PMID: 24821986.

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